Nanocarriers surface engineered with cell membranes for cancer targeted chemotherapy

Inspired by nature, the biomimetic approach has been incorporated into drug nanocarriers for cancer targeted chemotherapy. The nanocarriers are cloaked in cell membranes, which enables them to incorporate the functions of natural cells. Nanocarriers surface engineered with cell membranes have emerge...

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Bibliographic Details
Published in:Journal of nanobiotechnology 2022-01, Vol.20 (1), p.45-45, Article 45
Main Authors: Lei, Wen, Yang, Chen, Wu, Yi, Ru, Guoqing, He, Xianglei, Tong, Xiangmin, Wang, Shibing
Format: Article
Language:English
Subjects:
Analysis
Animals
Antigens
Biocompatibility
Biomimetics
Blood
Cancer
Cancer therapies
Carbohydrates
Care and treatment
Cell Line, Tumor
Cell Membrane
Cell membranes
Chemotherapy
Drug Carriers
Drug delivery
Drug delivery systems
Drug Delivery Systems - methods
Drugs
Health aspects
Humans
Immune system
Lipids
Lymphocytes
Manufacturing industry
Membranes
Metastasis
Methods
Mice
Nanocarriers
Nanoparticles
Nanotechnology
Neutrophils
Pathogens
Patient outcomes
Polyethylene glycol
Proteins
R&D
Research & development
Retention
Review
Reviews
Targeted drug delivery
Tumors
Vehicles
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Summary:Inspired by nature, the biomimetic approach has been incorporated into drug nanocarriers for cancer targeted chemotherapy. The nanocarriers are cloaked in cell membranes, which enables them to incorporate the functions of natural cells. Nanocarriers surface engineered with cell membranes have emerged as a fascinating source of materials for cancer targeted chemotherapy. A distinctive characteristic of cell membrane-coated nanocarriers (CMCNs) is that they include carbohydrates, proteins, and lipids, in addition to being biocompatible. CMCNs are capable of interacting with the complicated biological milieu of the tumor because they contain the signaling networks and intrinsic functions of their parent cells. Numerous cell membranes have been investigated for the purpose of masking nanocarriers with membranes, and various tumor-targeting methods have been devised to improve cancer targeted chemotherapy. Moreover, the diverse structure of the membrane from different cell sources broadens the spectrum of CMCNs and offers an entirely new class of drug-delivery systems. This review will describe the manufacturing processes for CMCNs and the therapeutic uses for different kinds of cell membrane-coated nanocarrier-based drug delivery systems, as well as addressing obstacles and future prospects.
ISSN:1477-3155
1477-3155
DOI:10.1186/s12951-022-01251-w