Polyphenol-rich peach (Prunus persica L.) by-product exerts a greater beneficial effect than dietary fiber-rich by-product on insulin resistance and hepatic steatosis in obese rats

•Fiber-rich peach by-product (DF-BP) showed a slight beneficial effect in obese rats.•Polyphenol-rich BP (PR-BP) reduced insulin resistance and hepatic steatosis.•PR-BP hypolipidemic effect was related to a reduced expression of lipogenic genes.•PR-BP beneficial effect was related to extractable and...

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Bibliographic Details
Published in:Journal of functional foods 2018-06, Vol.45, p.58-66
Main Authors: Rodríguez-González, Sarahí, Pérez-Ramírez, Iza F., Amaya-Cruz, Diana M., Gallegos-Corona, Marco A., Ramos-Gomez, Minerva, Mora, Ofelia, Reynoso-Camacho, Rosalía
Format: Article
Language:English
Subjects:
By-product
Dietary fiber
Hepatic steatosis
Insulin resistance
Peach
Polyphenols
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Summary:•Fiber-rich peach by-product (DF-BP) showed a slight beneficial effect in obese rats.•Polyphenol-rich BP (PR-BP) reduced insulin resistance and hepatic steatosis.•PR-BP hypolipidemic effect was related to a reduced expression of lipogenic genes.•PR-BP beneficial effect was related to extractable and non-extractable polyphenols. Peach juice by-product (PJBP) can prevent complications of obesity due to its high content of polyphenols and dietary fiber. This study aimed to evaluate the effect of a polyphenol-rich (PR-PJBP) and a dietary fiber-rich (DFR-PJBP) peach juice by-product on insulin resistance and hepatic steatosis in obese rats. Animals were fed with high fat and fructose diet (HFF) and supplemented with PR-PJBP and DFR-PJBP for eighteen weeks. PR-PJBP produced the greatest hypoglycemic effect by improving insulin resistance, increasing hepatic glycogen content, and decreasing hepatic PEPCK activity. Likewise, PR-PJBP decreased serum triglycerides levels, ameliorating hepatic steatosis, decreasing hepatic expression of Srebp1 and Fasn, and increasing hepatic Cpt1 expression. These results suggest that polyphenols from PJBP exert a greater beneficial effect on obesity-related complications than dietary fiber. These effects were associated with caffeoylquinic, p-coumaroylquinic and 4-feruloylquinic acids, and kaempferol derivatives. PR-PJBP could be used as an ingredient for the elaboration of functional foods.
ISSN:1756-4646
2214-9414
DOI:10.1016/j.jff.2018.03.010