The Ethnopharmacological Uses, Metabolite Diversity, and Bioactivity of Rhaponticum uniflorum (Leuzea uniflora): A Comprehensive Review

Rhaponticum uniflorum (L.) DC. (syn. Leuzea uniflora (L.) Holub) is a plant species of the Compositae (Asteraceae) family that is widely used in Asian traditional medicines in China, Siberia, and Mongolia as an anti-inflammatory and stimulant remedy. Currently, R. uniflorum is of scientific interest...

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Bibliographic Details
Published in:Biomolecules (Basel, Switzerland) Switzerland), 2022-11, Vol.12 (11), p.1720
Main Author: Olennikov, Daniil N.
Format: Article
Language:English
Subjects:
Analgesics
Arteriosclerosis
Biological activity
Breastfeeding & lactation
Bronchitis
Carbohydrates
Compositae (Asteraceae)
Ecdysteroids
Fatty acids
Flavonoids
Flowers & plants
Gastroenteritis
Herbal medicine
HPLC
Immunostimulation
Inflammation
Lung diseases
Medicinal plants
Medicine
Metabolites
Pneumonia
Review
Rhaponticum uniflorum
Rheumatoid arthritis
Sesquiterpenes
Skin diseases
Sterols
Stomach
thiophenes
Triterpenes
Triterpenoids
Tuberculosis
Ulcers
Vitamins
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Summary:Rhaponticum uniflorum (L.) DC. (syn. Leuzea uniflora (L.) Holub) is a plant species of the Compositae (Asteraceae) family that is widely used in Asian traditional medicines in China, Siberia, and Mongolia as an anti-inflammatory and stimulant remedy. Currently, R. uniflorum is of scientific interest to chemists, biologists, and pharmacologists, and this review includes information from the scientific literature from 1991 to 2022. The study of the chemodiversity of R. uniflorum revealed the presence of 225 compounds, including sesquiterpenes, ecdysteroids, triterpenes, sterols, thiophenes, hydroxycinnamates, flavonoids, lignans, nucleosides and vitamins, alkanes, fatty acids, and carbohydrates. The most studied groups of substances are phenolics (76 compounds) and triterpenoids (69 compounds). Information on the methods of chromatographic analysis of selected compounds, as well as on the quantitative content of some components in various organs of R. uniflorum, is summarized in this work. It has been shown that the extracts and some compounds of R. uniflorum have a wide range of biological activities, including anti-inflammatory, antitumor, immunostimulatory, anxiolytic, stress-protective, actoprotective, antihypoxic, anabolic, hepatoprotective, inhibition of PPARγ receptors, anti-atherosclerotic, and hypolipidemic. Published research on the metabolites and bioactivity of R. uniflorum does not include clinical studies of extracts and pure compounds; therefore, an accurate study of this traditional medicinal plant is needed.
ISSN:2218-273X
2218-273X
DOI:10.3390/biom12111720