Host-microbiome interactions: Gut-Liver axis and its connection with other organs

An understanding of connections between gut microbiome and liver has provided important insights into the pathophysiology of liver diseases. Since gut microbial dysbiosis increases gut permeability, the metabolites biosynthesized by them can reach the liver through portal circulation and affect hepa...

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Bibliographic Details
Published in:NPJ biofilms and microbiomes 2022-11, Vol.8 (1), p.89-89, Article 89
Main Authors: Anand, Swadha, Mande, Sharmila S.
Format: Article
Language:English
Subjects:
631/326/2565/2134
631/326/88
Bile acids
Biliary tract
Biomedical and Life Sciences
Dysbacteriosis
Intestinal microflora
Life Sciences
Liver
Liver diseases
Medical Microbiology
Metabolites
Microbial Ecology
Microbial Genetics and Genomics
Microbiology
Microbiomes
Permeability
Review
Review Article
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Summary:An understanding of connections between gut microbiome and liver has provided important insights into the pathophysiology of liver diseases. Since gut microbial dysbiosis increases gut permeability, the metabolites biosynthesized by them can reach the liver through portal circulation and affect hepatic immunity and inflammation. The immune cells activated by these metabolites can also reach liver through lymphatic circulation. Liver influences immunity and metabolism in multiple organs in the body, including gut. It releases bile acids and other metabolites into biliary tract from where they enter the systemic circulation. In this review, the bidirectional communication between the gut and the liver and the molecular cross talk between the host and the microbiome has been discussed. This review also provides details into the intricate level of communication and the role of microbiome in Gut-Liver-Brain, Gut-Liver-Kidney, Gut-Liver-Lung, and Gut-Liver-Heart axes. These observations indicate a complex network of interactions between host organs influenced by gut microbiome.
ISSN:2055-5008
2055-5008
DOI:10.1038/s41522-022-00352-6