An enzyme logic bioprotonic transducer

Translating ionic currents into measureable electronic signals is essential for the integration of bioelectronic devices with biological systems. We demonstrate the use of a Pd/PdHx electrode as a bioprotonic transducer that connects H+ currents in solution into an electronic signal. This transducer...

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Bibliographic Details
Published in:APL materials 2015-01, Vol.3 (1), p.014906-014906-6
Main Authors: Miyake, Takeo, Josberger, Erik E., Keene, Scott, Deng, Yingxin, Rolandi, Marco
Format: Article
Language:English
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Summary:Translating ionic currents into measureable electronic signals is essential for the integration of bioelectronic devices with biological systems. We demonstrate the use of a Pd/PdHx electrode as a bioprotonic transducer that connects H+ currents in solution into an electronic signal. This transducer exploits the reversible formation of PdHx in solution according to PdH↔Pd + H+ + e−, and the dependence of this formation on solution pH and applied potential. We integrate the protonic transducer with glucose dehydrogenase as an enzymatic and gate for glucose and NAD+. PdHx formation and associated electronic current monitors the output drop in pH, thus transducing a biological function into a measurable electronic output.
ISSN:2166-532X
2166-532X
DOI:10.1063/1.4900886