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Predictive factors for neuromotor abnormalities at the corrected age of 12 months in very low birth weight premature infants Fatores preditivos para anormalidades neuromotoras aos 12 meses de idade corrigida em prematuros de muito baixo peso

BACKGROUND: The increase in survival of premature newborns has sparked growing interest in the prediction of their long-term neurodevelopment. OBJECTIVE: To estimate the incidence of neuromotor abnormalities at the corrected age of 12 months and to identify the predictive factors associated with alt...

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Published in:Arquivos de neuro-psiquiatria 2009-06, Vol.67 (2a), p.235-241
Main Authors: Rosane Reis de Mello, Kátia Silveira da Silva, Maura Calixto Cecherelli de Rodrigues, Geórgia Chalfun, Rachel Carvalho Ferreira, Juliana Verçosa Rocha Delamônica
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container_issue 2a
container_start_page 235
container_title Arquivos de neuro-psiquiatria
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creator Rosane Reis de Mello
Kátia Silveira da Silva
Maura Calixto Cecherelli de Rodrigues
Geórgia Chalfun
Rachel Carvalho Ferreira
Juliana Verçosa Rocha Delamônica
description BACKGROUND: The increase in survival of premature newborns has sparked growing interest in the prediction of their long-term neurodevelopment. OBJECTIVE: To estimate the incidence of neuromotor abnormalities at the corrected age of 12 months and to identify the predictive factors associated with altered neuromotor development in very low birth weight premature infants. METHOD: Cohort study. The sample included 100 premature infants. The outcome was neuromotor development at 12 months classified by Bayley Scale (PDI) and neurological assessment (tonus, reflexes, posture). A multivariate logistic regression model was constructed. Neonatal variables and neuromotor abnormalities up to 6 months of corrected age were selected by bivariate analysis. RESULTS: Mean birth weight was 1126g (SD: 240). Abnormal neuromotor development was presented in 60 children at 12 months corrected age. CONCLUSION: According to the model, patients with a diagnosis including bronchopulmonary dysplasia, hypertonia of lower extremities, truncal hypotonia showed a 94.0% probability of neuromotor involvement at 12 months.INTRODUÇÃO: O aumento na sobrevida de recém-nascidos prematuros tem suscitado interesse crescente na predição do seu neurodesenvolvimento a longo prazo. OBJETIVO: Estimar a incidência de anormalidades neuromotoras aos 12 meses de idade corrigida e identificar os fatores associados ao desenvolvimento neuromotor alterado em prematuros de muito baixo peso. MÉTODO: Estudo de coorte. A amostra incluiu 100 crianças prematuras.O desfecho foi o desenvolvimento neuromotor aos 12 meses. Modelo de regressão logística multivariado foi construído. Variáveis neonatais e anormalidades neuromotoras até os 6 meses de idade corrigida foram selecionadas por análise bivariada. RESULTADOS: O peso de nascimento médio foi 1126g (DP:240). Aos 12 meses 60% das crianças apresentaram desenvolvimento neuromotor alterado. CONCLUSÃO: De acordo com o modelo, pacientes com diagnóstico incluindo displasia broncopulmonar, hipertonia de membros inferiores e hipotonia de tronco tinham 94% de probabilidade de comprometimento neuromotor aos 12 meses.
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OBJECTIVE: To estimate the incidence of neuromotor abnormalities at the corrected age of 12 months and to identify the predictive factors associated with altered neuromotor development in very low birth weight premature infants. METHOD: Cohort study. The sample included 100 premature infants. The outcome was neuromotor development at 12 months classified by Bayley Scale (PDI) and neurological assessment (tonus, reflexes, posture). A multivariate logistic regression model was constructed. Neonatal variables and neuromotor abnormalities up to 6 months of corrected age were selected by bivariate analysis. RESULTS: Mean birth weight was 1126g (SD: 240). Abnormal neuromotor development was presented in 60 children at 12 months corrected age. CONCLUSION: According to the model, patients with a diagnosis including bronchopulmonary dysplasia, hypertonia of lower extremities, truncal hypotonia showed a 94.0% probability of neuromotor involvement at 12 months.INTRODUÇÃO: O aumento na sobrevida de recém-nascidos prematuros tem suscitado interesse crescente na predição do seu neurodesenvolvimento a longo prazo. OBJETIVO: Estimar a incidência de anormalidades neuromotoras aos 12 meses de idade corrigida e identificar os fatores associados ao desenvolvimento neuromotor alterado em prematuros de muito baixo peso. MÉTODO: Estudo de coorte. A amostra incluiu 100 crianças prematuras.O desfecho foi o desenvolvimento neuromotor aos 12 meses. Modelo de regressão logística multivariado foi construído. Variáveis neonatais e anormalidades neuromotoras até os 6 meses de idade corrigida foram selecionadas por análise bivariada. RESULTADOS: O peso de nascimento médio foi 1126g (DP:240). Aos 12 meses 60% das crianças apresentaram desenvolvimento neuromotor alterado. CONCLUSÃO: De acordo com o modelo, pacientes com diagnóstico incluindo displasia broncopulmonar, hipertonia de membros inferiores e hipotonia de tronco tinham 94% de probabilidade de comprometimento neuromotor aos 12 meses.</description><identifier>ISSN: 0004-282X</identifier><identifier>EISSN: 1678-4227</identifier><identifier>DOI: 10.1590/S0004-282X2009000200012</identifier><language>eng</language><publisher>Academia Brasileira de Neurologia (ABNEURO)</publisher><subject>child development ; criança ; desempenho psicomotor ; desenvolvimento infantil ; fatores de risco ; infant ; premature ; prematuro ; psychomotor performance ; risk factors</subject><ispartof>Arquivos de neuro-psiquiatria, 2009-06, Vol.67 (2a), p.235-241</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Rosane Reis de Mello</creatorcontrib><creatorcontrib>Kátia Silveira da Silva</creatorcontrib><creatorcontrib>Maura Calixto Cecherelli de Rodrigues</creatorcontrib><creatorcontrib>Geórgia Chalfun</creatorcontrib><creatorcontrib>Rachel Carvalho Ferreira</creatorcontrib><creatorcontrib>Juliana Verçosa Rocha Delamônica</creatorcontrib><title>Predictive factors for neuromotor abnormalities at the corrected age of 12 months in very low birth weight premature infants Fatores preditivos para anormalidades neuromotoras aos 12 meses de idade corrigida em prematuros de muito baixo peso</title><title>Arquivos de neuro-psiquiatria</title><description>BACKGROUND: The increase in survival of premature newborns has sparked growing interest in the prediction of their long-term neurodevelopment. OBJECTIVE: To estimate the incidence of neuromotor abnormalities at the corrected age of 12 months and to identify the predictive factors associated with altered neuromotor development in very low birth weight premature infants. METHOD: Cohort study. The sample included 100 premature infants. The outcome was neuromotor development at 12 months classified by Bayley Scale (PDI) and neurological assessment (tonus, reflexes, posture). A multivariate logistic regression model was constructed. Neonatal variables and neuromotor abnormalities up to 6 months of corrected age were selected by bivariate analysis. RESULTS: Mean birth weight was 1126g (SD: 240). Abnormal neuromotor development was presented in 60 children at 12 months corrected age. CONCLUSION: According to the model, patients with a diagnosis including bronchopulmonary dysplasia, hypertonia of lower extremities, truncal hypotonia showed a 94.0% probability of neuromotor involvement at 12 months.INTRODUÇÃO: O aumento na sobrevida de recém-nascidos prematuros tem suscitado interesse crescente na predição do seu neurodesenvolvimento a longo prazo. OBJETIVO: Estimar a incidência de anormalidades neuromotoras aos 12 meses de idade corrigida e identificar os fatores associados ao desenvolvimento neuromotor alterado em prematuros de muito baixo peso. MÉTODO: Estudo de coorte. A amostra incluiu 100 crianças prematuras.O desfecho foi o desenvolvimento neuromotor aos 12 meses. Modelo de regressão logística multivariado foi construído. Variáveis neonatais e anormalidades neuromotoras até os 6 meses de idade corrigida foram selecionadas por análise bivariada. RESULTADOS: O peso de nascimento médio foi 1126g (DP:240). Aos 12 meses 60% das crianças apresentaram desenvolvimento neuromotor alterado. CONCLUSÃO: De acordo com o modelo, pacientes com diagnóstico incluindo displasia broncopulmonar, hipertonia de membros inferiores e hipotonia de tronco tinham 94% de probabilidade de comprometimento neuromotor aos 12 meses.</description><subject>child development</subject><subject>criança</subject><subject>desempenho psicomotor</subject><subject>desenvolvimento infantil</subject><subject>fatores de risco</subject><subject>infant</subject><subject>premature</subject><subject>prematuro</subject><subject>psychomotor performance</subject><subject>risk factors</subject><issn>0004-282X</issn><issn>1678-4227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNqtkE1Ow0AMhUcIJMrPGfAFCpN0SpM1ooIdEizYRU7iJFMlceWZtvTY3AC3quACrGzP-_Te0xhzl9j7ZJ7bh3drrZumWfqZWpvrocMm6ZmZJI-LbOrSdHFuJr_QpbkKYaWUy_PFxHy_CdW-in5L0GAVWQI0LDDSRnhgvQHLkWXA3kdPATBC7AgqFqEqUg3YEnADSQoDj7EL4EfYkuyh5x2UXmIHO_JtF2EtNGDcCCnS4BgDLFED1HR9KKEdWFcUBDwl1lir-tcFNV-ZQxYFVWq1OjDHOr7VHWj4zeEjMGx8ZCjRfzGsKfCNuWiwD3R7mtfmdfn88fQyrRlXxVr8gLIvGH1xfGBpC5Toq56KLM-T2pZzWzp0jdP_cqXLcD5zToV8NvtPrx-ovJ1I</recordid><startdate>20090601</startdate><enddate>20090601</enddate><creator>Rosane Reis de Mello</creator><creator>Kátia Silveira da Silva</creator><creator>Maura Calixto Cecherelli de Rodrigues</creator><creator>Geórgia Chalfun</creator><creator>Rachel Carvalho Ferreira</creator><creator>Juliana Verçosa Rocha Delamônica</creator><general>Academia Brasileira de Neurologia (ABNEURO)</general><scope>DOA</scope></search><sort><creationdate>20090601</creationdate><title>Predictive factors for neuromotor abnormalities at the corrected age of 12 months in very low birth weight premature infants Fatores preditivos para anormalidades neuromotoras aos 12 meses de idade corrigida em prematuros de muito baixo peso</title><author>Rosane Reis de Mello ; Kátia Silveira da Silva ; Maura Calixto Cecherelli de Rodrigues ; Geórgia Chalfun ; Rachel Carvalho Ferreira ; Juliana Verçosa Rocha Delamônica</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-doaj_primary_oai_doaj_org_article_8991d0b50b4a4f4fac4b48a534491d933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>child development</topic><topic>criança</topic><topic>desempenho psicomotor</topic><topic>desenvolvimento infantil</topic><topic>fatores de risco</topic><topic>infant</topic><topic>premature</topic><topic>prematuro</topic><topic>psychomotor performance</topic><topic>risk factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rosane Reis de Mello</creatorcontrib><creatorcontrib>Kátia Silveira da Silva</creatorcontrib><creatorcontrib>Maura Calixto Cecherelli de Rodrigues</creatorcontrib><creatorcontrib>Geórgia Chalfun</creatorcontrib><creatorcontrib>Rachel Carvalho Ferreira</creatorcontrib><creatorcontrib>Juliana Verçosa Rocha Delamônica</creatorcontrib><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Arquivos de neuro-psiquiatria</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rosane Reis de Mello</au><au>Kátia Silveira da Silva</au><au>Maura Calixto Cecherelli de Rodrigues</au><au>Geórgia Chalfun</au><au>Rachel Carvalho Ferreira</au><au>Juliana Verçosa Rocha Delamônica</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictive factors for neuromotor abnormalities at the corrected age of 12 months in very low birth weight premature infants Fatores preditivos para anormalidades neuromotoras aos 12 meses de idade corrigida em prematuros de muito baixo peso</atitle><jtitle>Arquivos de neuro-psiquiatria</jtitle><date>2009-06-01</date><risdate>2009</risdate><volume>67</volume><issue>2a</issue><spage>235</spage><epage>241</epage><pages>235-241</pages><issn>0004-282X</issn><eissn>1678-4227</eissn><abstract>BACKGROUND: The increase in survival of premature newborns has sparked growing interest in the prediction of their long-term neurodevelopment. OBJECTIVE: To estimate the incidence of neuromotor abnormalities at the corrected age of 12 months and to identify the predictive factors associated with altered neuromotor development in very low birth weight premature infants. METHOD: Cohort study. The sample included 100 premature infants. The outcome was neuromotor development at 12 months classified by Bayley Scale (PDI) and neurological assessment (tonus, reflexes, posture). A multivariate logistic regression model was constructed. Neonatal variables and neuromotor abnormalities up to 6 months of corrected age were selected by bivariate analysis. RESULTS: Mean birth weight was 1126g (SD: 240). Abnormal neuromotor development was presented in 60 children at 12 months corrected age. CONCLUSION: According to the model, patients with a diagnosis including bronchopulmonary dysplasia, hypertonia of lower extremities, truncal hypotonia showed a 94.0% probability of neuromotor involvement at 12 months.INTRODUÇÃO: O aumento na sobrevida de recém-nascidos prematuros tem suscitado interesse crescente na predição do seu neurodesenvolvimento a longo prazo. OBJETIVO: Estimar a incidência de anormalidades neuromotoras aos 12 meses de idade corrigida e identificar os fatores associados ao desenvolvimento neuromotor alterado em prematuros de muito baixo peso. MÉTODO: Estudo de coorte. A amostra incluiu 100 crianças prematuras.O desfecho foi o desenvolvimento neuromotor aos 12 meses. Modelo de regressão logística multivariado foi construído. Variáveis neonatais e anormalidades neuromotoras até os 6 meses de idade corrigida foram selecionadas por análise bivariada. RESULTADOS: O peso de nascimento médio foi 1126g (DP:240). Aos 12 meses 60% das crianças apresentaram desenvolvimento neuromotor alterado. CONCLUSÃO: De acordo com o modelo, pacientes com diagnóstico incluindo displasia broncopulmonar, hipertonia de membros inferiores e hipotonia de tronco tinham 94% de probabilidade de comprometimento neuromotor aos 12 meses.</abstract><pub>Academia Brasileira de Neurologia (ABNEURO)</pub><doi>10.1590/S0004-282X2009000200012</doi><oa>free_for_read</oa></addata></record>
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source SciELO Brazil
subjects child development
criança
desempenho psicomotor
desenvolvimento infantil
fatores de risco
infant
premature
prematuro
psychomotor performance
risk factors
title Predictive factors for neuromotor abnormalities at the corrected age of 12 months in very low birth weight premature infants Fatores preditivos para anormalidades neuromotoras aos 12 meses de idade corrigida em prematuros de muito baixo peso
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