The multifaceted roles of long noncoding RNAs in pancreatic cancer: an update on what we know

Pancreatic cancer (PC) is one of the leading causes of cancer-related deaths worldwide. Due to the shortage of effective biomarkers for predicting survival and diagnosing PC, the underlying mechanism is still intensively investigated but poorly understood. Long noncoding RNAs (lncRNAs) provide biolo...

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Bibliographic Details
Published in:Cancer cell international 2020-02, Vol.20 (1), p.41-41, Article 41
Main Authors: Zhou, Wenjia, Chen, Lu, Li, Chao, Huang, Rui, Guo, Mian, Ning, Shangwei, Ji, Jingjing, Guo, Xiaorong, Lou, Ge, Jia, Xinqi, Zhao, Junjie, Luo, Feng, Li, Chunlong, Qu, Zhaowei, Yu, Shan, Tai, Sheng
Format: Article
Language:English
Subjects:
Apoptosis
Autophagy
Biomarkers
Cancer therapies
Cell growth
Epigenetics
Fatalities
Gene expression
Kinases
Long noncoding RNAs
Mechanisms
Medical prognosis
Medical research
Metastasis
Pancreatic cancer
Phosphorylation
Proteins
Review
Survival
Tumorigenesis
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Summary:Pancreatic cancer (PC) is one of the leading causes of cancer-related deaths worldwide. Due to the shortage of effective biomarkers for predicting survival and diagnosing PC, the underlying mechanism is still intensively investigated but poorly understood. Long noncoding RNAs (lncRNAs) provide biological functional diversity and complexity in protein regulatory networks. Scientific studies have revealed the emerging functions and regulatory roles of lncRNAs in PC behaviors. It is worth noting that some in-depth studies have revealed that lncRNAs are significantly associated with the initiation and progression of PC. As lncRNAs have good properties for both diagnostic and prognostic prediction due to their translation potential, we herein address the current understanding of the multifaceted roles of lncRNAs as regulators in the molecular mechanism of PC. We also discuss the possibility of using lncRNAs as survival biomarkers and their contributions to the development of targeted therapies based on the literature. The present review, based on what we know about current research findings, may help us better understand the roles of lncRNAs in PC.
ISSN:1475-2867
1475-2867
DOI:10.1186/s12935-020-1126-1