Betulinic Acid Increases the Lifespan of Drosophila melanogaster via Sir2 and FoxO Activation

Betulinic acid (BetA), a triterpenoid derivative found abundantly in the plant kingdom, has emerged as a promising candidate for promoting longevity. Many research studies have shown its antioxidant, anti-inflammatory, antiviral, and anticancer activities, making it an interesting subject for invest...

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Bibliographic Details
Published in:Nutrients 2024-02, Vol.16 (3), p.441
Main Authors: Lee, Hye-Yeon, Min, Kyung-Jin
Format: Article
Language:English
Subjects:
Acids
anti-aging effect
Antioxidants
betulinic acid
Diet
Drosophila melanogaster
Experiments
Females
Food
Glycerol
Insects
Kinases
lifespan
Physiology
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Summary:Betulinic acid (BetA), a triterpenoid derivative found abundantly in the plant kingdom, has emerged as a promising candidate for promoting longevity. Many research studies have shown its antioxidant, anti-inflammatory, antiviral, and anticancer activities, making it an interesting subject for investigating its potential influence on lifespan. This study aimed to investigate the effects of BetA on longevity and the mechanisms associated with it using the fruit fly as the organism model. The results showed that 50 μM BetA supplementation extended the mean lifespan of fruit flies by 13% in males and 6% in females without any adverse effects on their physiology, such as fecundity, feeding rate, or locomotion ability reduction. However, 50 μM BetA supplementation failed to increase the lifespan in mutants lacking functional silent information regulator 2 (Sir2) and Forkhead box O (FoxO)-null, implying that the longevity effect of BetA is related to Sir2 and FoxO activation. Our study contributes to the knowledge in the field of anti-aging research and inspires further investigations into natural compounds such as BetA to enhance organismal healthspan.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu16030441