From design to clinic: Engineered peptide nanomaterials for cancer immunotherapy

Immunotherapy has revolutionized the field of cancer therapy. Nanomaterials can further improve the efficacy and safety of immunotherapy because of their tunability and multifunctionality. Owing to their natural biocompatibility, diverse designs, and dynamic self-assembly, peptide-based nanomaterial...

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Bibliographic Details
Published in:Frontiers in chemistry 2023-01, Vol.10, p.1107600-1107600
Main Authors: Du, Jing-Jing, Su, Zhenhong, Yu, Haoyi, Qin, Sanhai, Wang, Dongyuan
Format: Article
Language:English
Subjects:
cancer immunotherapy
Chemistry
clinic
nanomaterials
peptide
vaccines
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Summary:Immunotherapy has revolutionized the field of cancer therapy. Nanomaterials can further improve the efficacy and safety of immunotherapy because of their tunability and multifunctionality. Owing to their natural biocompatibility, diverse designs, and dynamic self-assembly, peptide-based nanomaterials hold great potential as immunotherapeutic agents for many malignant cancers, with good immune response and safety. Over the past several decades, peptides have been developed as tumor antigens, effective antigen delivery carriers, and self-assembling adjuvants for cancer immunotherapy. In this review, we give a brief introduction to the use of peptide-based nanomaterials for cancer immunotherapy as antigens, carriers, and adjuvants, and to their current clinical applications. Overall, this review can facilitate further understanding of peptide-based nanomaterials for cancer immunotherapy and may pave the way for designing safe and efficient methods for future vaccines or immunotherapies.
ISSN:2296-2646
2296-2646
DOI:10.3389/fchem.2022.1107600