The incidence risk of gynecological cancer by antipsychotic use: a meta-analysis of 50,402 patients

Female gynecological cancers represent a serious public health problem, with 1,398,601 new diagnoses and 671,875 deaths per year worldwide. Antipsychotics are often used in psychiatric disorders, including schizophrenia, bipolar disorder, and major depression. It is estimated that the prescription o...

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Bibliographic Details
Published in:BMC cancer 2024-06, Vol.24 (1), p.712-10
Main Authors: de Moraes, Francisco Cezar Aquino, Sudo, Renan Yuji Ura, Souza, Maria Eduarda Cavalcanti, Fernandes, Marianne Rodrigues, Dos Santos, Ney Pereira Carneiro
Format: Article
Language:English
Subjects:
Antipsychotic Agents - adverse effects
Antipsychotic Agents - therapeutic use
Antipsychotic drugs
Antipsychotics
Bipolar disorder
Cancer
Cancer therapies
Citation management software
Complications and side effects
Depression, Mental
Diabetes
Dosage and administration
Drug Side effects
Endometrial cancer
Endometrial Neoplasms - chemically induced
Endometrial Neoplasms - epidemiology
Endometrium
Epidemiology
Female
Genital cancer
Genital Neoplasms, Female - drug therapy
Genital Neoplasms, Female - epidemiology
Gynecological cancer
Gynecology
Health aspects
Humans
Hypertension
Incidence
Mental disorders
Meta-analysis
Mortality
Observational studies
Odds Ratio
Oncology, Experimental
Online databases
Ovarian cancer
Ovarian Neoplasms - drug therapy
Ovarian Neoplasms - epidemiology
Physiological aspects
Psychotropic drugs
Public health
Risk Factors
Schizophrenia
Statistical analysis
Statistics
Systematic review
Thioridazine
Trifluoperazine
Tumors
Uterine cancer
Vagina
Womens health
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Summary:Female gynecological cancers represent a serious public health problem, with 1,398,601 new diagnoses and 671,875 deaths per year worldwide. Antipsychotics are often used in psychiatric disorders, including schizophrenia, bipolar disorder, and major depression. It is estimated that the prescription of these drugs is linked to 1,800 deaths a year in the United States, but their association with cancer remains controversial. We searched PubMed, Scopus, and Web of Science databases for studies reporting the correlation in the incidence risk of gynecological cancer by antipsychotic use. We used DerSimonian and Laird random-effect models to compute logit transformed odds ratio (OR) for the primary binary endpoint with 95% confidence interval (CI). Heterogeneity was assessed through effect size width along with I-squared and Tau-squared statistics. Review Manager 5.4.1. was used for statistical analyses. A p-value of
ISSN:1471-2407
1471-2407
DOI:10.1186/s12885-024-12481-6