Key biomarkers within the colorectal cancer related inflammatory microenvironment

Therapeutic approaches focused on the inflammatory microenvironment are currently gaining more support, as biomolecules involved in the inflammatory colorectal cancer (CRC) tumor microenvironment are being explored. We analyzed tumor and paired normal tissue samples from CRC patients (n = 22) whom u...

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Bibliographic Details
Published in:Scientific reports 2021-04, Vol.11 (1), p.7940-7940, Article 7940
Main Authors: Calu, Valentin, Ionescu, Adriana, Stanca, Loredana, Geicu, Ovidiu Ionut, Iordache, Florin, Pisoschi, Aurelia Magdalena, Serban, Andreea Iren, Bilteanu, Liviu
Format: Article
Language:English
Subjects:
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APRIL protein
Biomarkers
BLyS protein
CD163 antigen
Chitinase
Colorectal cancer
Colorectal carcinoma
Correlation coefficient
Enzyme-linked immunosorbent assay
Gelatinase A
Humanities and Social Sciences
Inflammation
Interleukin 8
Metastases
multidisciplinary
Science
Science (multidisciplinary)
Stat1 protein
Stat3 protein
Statistical analysis
Surgery
Transcription factors
Tumor microenvironment
Tumors
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Summary:Therapeutic approaches focused on the inflammatory microenvironment are currently gaining more support, as biomolecules involved in the inflammatory colorectal cancer (CRC) tumor microenvironment are being explored. We analyzed tumor and paired normal tissue samples from CRC patients (n = 22) whom underwent tumor resection surgery. We assessed 39 inflammation-involved biomolecules (multiplex magnetic bead-based immunoassay), CEA and CA19-9 (ELISA assay) and the tissue expression levels of occludin and also pErk, STAT1 and STAT3 transcriptional factors (western blot). Tumor staging has been established by histopathological evaluation of HE stained tumor tissue sections. We report 32 biomarkers displaying statistically significant differences in tumor vs. control. Additionally, positive statistical biomarker correlations were found between MMP2–IL8 and BAFF–IL8 (Pearson correlation coefficients > 0.751), while APRIL–MMP2, APRIL–BAFF and APRIL–IL8 were negatively correlated (correlation coefficients 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-86941-5