Fibrinolytic Therapy in Thrombosis of Mechanical Valves: Outcomes and Complications

Valvular heart disease presents a significant and escalating global health challenge. Prosthetic valve thrombosis (PVT) following surgical valve replacement is a primary cause of valve failure. The aim of this study was to ascertain the outcomes and complications of fibrinolytic therapy in patients...

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Bibliographic Details
Published in:ARYA atherosclerosis 2023-09, Vol.19 (5), p.18-219
Main Authors: Nasri Nasrabadi, Ali, Yarahmadi, Fahimeh, Amirpour, Afshin, Zavar, Reyhaneh, Akbari, Mojtaba
Format: Article
Language:English
Subjects:
Cardiovascular disease
Cross-sectional studies
Developing countries
fibrinolytic therapy
Heart
Hemorrhage
LDCs
Medical records
Mortality
Original
Patients
Prostheses
prosthetic valve thrombosis
reteplase
streptokinase
Stroke
Success
Surgery
Thrombosis
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Summary:Valvular heart disease presents a significant and escalating global health challenge. Prosthetic valve thrombosis (PVT) following surgical valve replacement is a primary cause of valve failure. The aim of this study was to ascertain the outcomes and complications of fibrinolytic therapy in patients diagnosed with PVT. This cross-sectional study enrolled 81 patients diagnosed with PVT who underwent fibrinolytic therapy between 2008 and 2018. Streptokinase was administered to 87.6% of patients, while 12.4% received reteplase. All demographic and clinical data were gathered from the patients' medical records. The incidence of successful recovery and complications were assessed. The records of 81 patients (43.2% male, mean age: 51.6 ± 13.9 years) were examined. The findings revealed that 59% and 35% of the patients had mitral and aortic PVT, respectively. While 12% of the patients experienced drug complications, 90% achieved successful recovery. Stroke and severe hemorrhage were complications frequently reported by the patients treated with streptokinase (8% and 4% respectively). The patients treated with reteplase demonstrated a 100% recovery rate. Conversely, 89% of the patients treated with streptokinase achieved successful recovery, and 7% of the patients experienced a partial recovery. Fibrinolytic agents can serve as an effective treatment with an excellent success rate for managing PVT in patients post-surgical valve replacement.
ISSN:1735-3955
2251-6638
DOI:10.48305/arya.2023.26569.2804