Prognosis of pregnancy-associated breast cancer: a meta-analysis

Pregnancy-associated breast cancer (PABC) is defined as breast cancer that is diagnosed during pregnancy and/or the postpartum period. Definitions of the duration of the postpartum period have been controversial, and this variability may lead to diverse results regarding prognosis. Moreover, evidenc...

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Bibliographic Details
Published in:BMC cancer 2020-08, Vol.20 (1), p.746-746, Article 746
Main Authors: Shao, Chunchun, Yu, Zhigang, Xiao, Juan, Liu, Liyuan, Hong, Fanzhen, Zhang, Yuan, Jia, Hongying
Format: Article
Language:English
Subjects:
Analysis
Breast cancer
Breast Neoplasms - mortality
Confidence Intervals
Delivery, Obstetric
Diagnosis
Disease-Free Survival
Dose-response
Female
Health aspects
Humans
Least-Squares Analysis
Medical diagnosis
Medical prognosis
Meta-analysis
Mortality
Parity
Postpartum
Pregnancy
Pregnancy Complications, Neoplastic - mortality
Pregnancy-associated breast cancer
Pregnant women
Prognosis
Proportional Hazards Models
Studies
Survival
Time Factors
Womens health
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Summary:Pregnancy-associated breast cancer (PABC) is defined as breast cancer that is diagnosed during pregnancy and/or the postpartum period. Definitions of the duration of the postpartum period have been controversial, and this variability may lead to diverse results regarding prognosis. Moreover, evidence on the dose-response association between the time from the last pregnancy to breast cancer diagnosis and overall mortality has not been synthesized. We systematically searched PubMed, Embase, and the Cochrane Library for observational studies on the prognosis of PABC published up to June 1, 2019. We estimated summary-adjusted hazard ratios (HRs) and the corresponding 95% confidence intervals (CIs). Subgroup analyses based on diagnosis time, PABC definition, geographic region, year of publication and estimation procedure for HR were performed. Additionally, dose-response analysis was conducted by using the variance weighted least-squares regression (VWLS) trend estimation. A total of 54 articles (76 studies) were included in our study. PABC was associated with poor prognosis for overall survival (OS), disease-free survival (DFS) and cause-specific survival (CSS), and the pooled HRs with 95% CIs were 1.45 (1.30-1.63), 1.39 (1.25-1.54) and 1.40 (1.17-1.68), respectively. The corresponding reference category was non-PABC patients. According to subgroup analyses, the varied definition of PABC led to diverse results. The dose-response analysis indicated a nonlinear association between the time from the last delivery to breast cancer diagnosis and the HR of overall mortality (P 
ISSN:1471-2407
1471-2407
DOI:10.1186/s12885-020-07248-8