Chlorogenic Acid Ameliorates Post‐Infectious Irritable Bowel Syndrome by Regulating Extracellular Vesicles of Gut Microbes

Post‐infectious irritable bowel syndrome (PI‐IBS) occurs after acute infectious diarrhea, and dysbiosis can be involved in its pathogenesis. Here, the role of chlorogenic acid (CGA) is investigated, a natural compound with several pharmacological properties, in alleviating PI‐IBS in rats. It is eluc...

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Published in:Advanced science 2023-10, Vol.10 (28), p.e2302798-e2302798
Main Authors: Zheng, Cihua, Zhong, Yuchun, Zhang, Wenming, Wang, Zhuoya, Xiao, Haili, Zhang, Wenjun, Xie, Jian, Peng, Xiaogang, Luo, Jun, Xu, Wei
Format: Article
Language:English
Subjects:
Bacteria
bacteroides acidifaciens
chlorogenic acid
Colon
Cytokines
Extracellular vesicles
glycine
Gram-positive bacteria
Irritable bowel syndrome
Kinases
Metabolites
Microbiota
Permeability
PI‐IBS
Post traumatic stress disorder
Proteins
Tumor necrosis factor-TNF
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container_issue 28
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container_title Advanced science
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creator Zheng, Cihua
Zhong, Yuchun
Zhang, Wenming
Wang, Zhuoya
Xiao, Haili
Zhang, Wenjun
Xie, Jian
Peng, Xiaogang
Luo, Jun
Xu, Wei
description Post‐infectious irritable bowel syndrome (PI‐IBS) occurs after acute infectious diarrhea, and dysbiosis can be involved in its pathogenesis. Here, the role of chlorogenic acid (CGA) is investigated, a natural compound with several pharmacological properties, in alleviating PI‐IBS in rats. It is elucidated that the gut microbiota plays a key role in PI‐IBS pathogenesis and that rectal administration of CGA alleviated PI‐IBS by modulating the gut microbiota and its metabolites. CGA supplementation significantly increased fecal Bacteroides acidifaciens abundance and glycine levels. Glycine structurally altered B. acidifacien s extracellular vesicles (EVs) and enriched functional proteins in the EVs; glycine‐induced EVs alleviated PI‐IBS by reducing inflammation and hypersensitivity of the intestinal viscera and maintaining mucosal barrier function. Moreover, B. acidifacien s EVs are enriched in the brain tissue. Thus, CGA mediates the mitigation of PI‐IBS through the gut microbiota and its metabolites. This study proposes a novel mechanism of signal exchange between the gut microenvironment and the host.
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subjects Bacteria
bacteroides acidifaciens
chlorogenic acid
Colon
Cytokines
Extracellular vesicles
glycine
Gram-positive bacteria
Irritable bowel syndrome
Kinases
Metabolites
Microbiota
Permeability
PI‐IBS
Post traumatic stress disorder
Proteins
Tumor necrosis factor-TNF
title Chlorogenic Acid Ameliorates Post‐Infectious Irritable Bowel Syndrome by Regulating Extracellular Vesicles of Gut Microbes
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