Selected cardiac abnormalities in Trypanosoma cruzi serologically positive, discordant, and negative working dogs along the Texas-Mexico border

Chagas disease is increasingly recognized in the southern U.S., where triatomine vectors transmit Trypanosoma cruzi among wildlife and domestic dogs with occasional vector spillover to humans. As in humans, clinical outcome in dogs is variable, ranging from acute death to asymptomatic infections or...

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Bibliographic Details
Published in:BMC veterinary research 2020-03, Vol.16 (1), p.101-101, Article 101
Main Authors: Meyers, Alyssa C, Ellis, Megan M, Purnell, Julia C, Auckland, Lisa D, Meinders, Marvin, Saunders, Ashley B, Hamer, Sarah A
Format: Article
Language:English
Subjects:
Analysis
Calcium-binding protein
Cardiac arrhythmia
Cardiac troponin I
Cardiomyocytes
Cardiomyopathy
Chagas disease
Coronary artery disease
Diseases
Dog
Dogs
EKG
Electrocardiogram
Electrocardiography
Epidemiology
Health aspects
Heart diseases
Heart rate
Infections
Medical prognosis
Medical research
Parasites
Protozoa
Texas
Troponin
Troponin I
Trypanosoma cruzi
Ventricle
Wildlife
Zoonoses
Zoonotic disease
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Summary:Chagas disease is increasingly recognized in the southern U.S., where triatomine vectors transmit Trypanosoma cruzi among wildlife and domestic dogs with occasional vector spillover to humans. As in humans, clinical outcome in dogs is variable, ranging from acute death to asymptomatic infections or chronic heart disease. In order to characterize cardiac manifestations of T. cruzi infections, we tracked a cohort of naturally-infected dogs and a matched cohort of uninfected dogs. We hypothesized that selected measures of cardiac disease (abnormal rate, abnormal rhythm, and elevated cardiac troponin I (cTnI; a biomarker of cardiac injury)) would occur more commonly in infected than uninfected dogs matched by age, breed, sex and location. In addition to the clearly positive and negative dogs, we specifically tracked dogs with discordant test results across three independent serological assays to gather clinical data that might elucidate the infection status of these animals and inform the utility of the different testing approaches. We placed an ambulatory ECG monitor (Holter) on 48 government working dogs and analyzed 39 successful recordings that met length and quality criteria from 17 T. cruzi-infected, 18 uninfected dogs and 4 dogs with discordant results. Overall, 76.5% of positive, 100.0% of discordant, and 11.1% of negative dogs showed > 1 ECG abnormality (p 
ISSN:1746-6148
1746-6148
DOI:10.1186/s12917-020-02322-6