Mitochondrial haplogroup H is related to CD4+ T cell recovery in HIV infected patients starting combination antiretroviral therapy

The mitochondrial DNA (mtDNA) seems to influence in a large number of diseases, including HIV infection. Moreover, there is a substantial inter-individual variability in the CD4+ recovery in HIV-infected patients on combination antiretroviral therapy (cART). Our study aimed to analyze the associatio...

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Bibliographic Details
Published in:Journal of translational medicine 2018-12, Vol.16 (1), p.343-343, Article 343
Main Authors: Medrano, Luz M, Gutiérrez-Rivas, Mónica, Blanco, Julià, García, Marcial, Jiménez-Sousa, María A, Pacheco, Yolanda M, Montero, Marta, Iribarren, José Antonio, Bernal, Enrique, Martínez, Onofre Juan, Benito, José M, Rallón, Norma, Resino, Salvador
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
AIDS
Antiretroviral agents
Antiretroviral drugs
Antiretroviral therapy
cART
CD4 antigen
Genotyping
Haplogroups
HIV
Human immunodeficiency virus
Immune reconstitution
Lymphocytes
Lymphocytes T
Mitochondria
Mitochondrial DNA
mtDNA
Regression analysis
Systematic review
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Summary:The mitochondrial DNA (mtDNA) seems to influence in a large number of diseases, including HIV infection. Moreover, there is a substantial inter-individual variability in the CD4+ recovery in HIV-infected patients on combination antiretroviral therapy (cART). Our study aimed to analyze the association between mtDNA haplogroups and CD4+ recovery in HIV-infected patients on cART. This is a retrospective study of 324 naïve cART patients with CD4+
ISSN:1479-5876
1479-5876
DOI:10.1186/s12967-018-1717-y