A population-based prospective study on rest-activity rhythm and mild cognitive impairment among Hong Kong healthy community-dwelling older adults

• Published in: Neurobiology of sleep and circadian rhythms 2021-05, Vol.10, p.100065-100065, Article 100065
• Main Authors: Yi Lee, Priscilla Ming, Ling Kwok, Bonnie Ho, Ting Ma, Julie Yuen, Tse, Lap Ah
• Format: Article
• Language: English
• Subjects: Actigraphy; Circadian rhythm; Cognition; Cohort studies; Elderly; Research Paper
• ISSN: 2451-9944; 2451-9944
• DOI: 10.1016/j.nbscr.2021.100065

Relatively few studies investigated the association between rest-activity circadian rhythm and cognitive impairment in population-based study, and the evidence from Asian populations is sparse. We aimed to examine the relationship of actigraphy measured rest-activity circadian rhythm with mild cognitive impairment (MCI) or cognitive impairment in Hong Kong healthy community-dwelling older adults. We recruited 174 Hong Kong healthy adults aged ≥65 years (36 male vs. 138 female) during April–September 2018, and followed up them for 12 months. Participants were invited to wear wrist actigraphy for 7 days in both baseline and follow-up study. We used the actigraph data to calculate their midline statistic of rhythm (MESOR), amplitude, acrophase and percent rhythm. Montreal Cognitive Assessment (MoCA) was used to assess their cognitive scores at baseline and follow-up. Multivariate logistic regression model was performed to estimate the association of rest-activity circadian rhythm parameters with MCI; whilst multinomial logistic regression model was used to examine the association between rhythm parameters and changes of cognitive scores (i.e., worsen: