An Unusual Case of Cushing’s Syndrome: Coexistence of Functional Pituitary and Adrenal Adenoma

A case of adrenocorticotropic hormone (ACTH)-independent Cushing’s syndrome, which develops in the course of ACTH-dependent Cushing’s disease, is presented in this report. A 47-year-old woman with a past history of surgery and gamma knife radiosurgery because of Cushing’s disease was admitted to the...

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Bibliographic Details
Published in:Haseki tıp bülteni 2017-03, Vol.55 (1), p.61-63
Main Authors: İlhan, Muzaffer, Karaman, Özcan, Yasin Çetin, İrem, Büyükpınarbaşılı, Nur, Hamdard, Jamshid, Taşan, Ertuğrul
Format: Article
Language:English
Subjects:
Abdomen
adrenal adenoma
Adrenal glands
Cushing syndrome
Cushing’s disease
Cushing’s syndrome
Endocrinology
Glucose
Growth hormones
Neuroendocrine tumors
NMR
Nuclear magnetic resonance
Sağlık Hizmetleri
Sinuses
Surgery
Tıp
Tumors
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Summary:A case of adrenocorticotropic hormone (ACTH)-independent Cushing’s syndrome, which develops in the course of ACTH-dependent Cushing’s disease, is presented in this report. A 47-year-old woman with a past history of surgery and gamma knife radiosurgery because of Cushing’s disease was admitted to the endocrinology clinic with weight gain and unregulated blood glucose levels. Hypercortisolemia was still persisting and diagnostic work-up indicated ACTH-independent Cushing’s syndrome. Along with the rare possibility of this coexistence, longstanding ACTH hypersecretion can play a role in functional transition of adrenal adenomas. Further studies are needed to clarify the underlying mechanisms.
ISSN:1302-0072
2147-2688
DOI:10.4274/haseki.3073