Detection of MET Alterations Using Cell Free DNA and Circulating Tumor Cells from Cancer Patients

MET alterations may provide a potential biomarker to evaluate patients who will benefit from treatment with MET inhibitors. Therefore, the purpose of the present study is to investigate the utility of a liquid biopsy-based strategy to assess MET alterations in cancer patients. We analyzed amplificat...

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Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2020-02, Vol.9 (2), p.522
Main Authors: Mondelo-Macía, Patricia, Rodríguez-López, Carmela, Valiña, Laura, Aguín, Santiago, León-Mateos, Luis, García-González, Jorge, Abalo, Alicia, Rapado-González, Oscar, Suárez-Cunqueiro, Mercedes, Díaz-Lagares, Angel, Curiel, Teresa, Calabuig-Fariñas, Silvia, Azkárate, Aitor, Obrador-Hevia, Antònia, Abdulkader, Ihab, Muinelo-Romay, Laura, Diaz-Peña, Roberto, López-López, Rafael
Format: Article
Language:English
Subjects:
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Biomarkers
Biomarkers, Tumor - blood
Biomarkers, Tumor - genetics
Biopsy
Cancer therapies
Case-Control Studies
Cell growth
Cell-Free Nucleic Acids - blood
circulating free dna (cfdna)
circulating tumor cells (ctcs)
Colorectal cancer
Copy number
Deoxyribonucleic acid
DNA
Drug Resistance, Neoplasm - genetics
Epidermal growth factor receptors
ErbB Receptors - antagonists & inhibitors
Female
Gastric cancer
Gene Dosage
Growth factors
Head & neck cancer
Humans
Kinases
Liquid Biopsy
Male
Medical prognosis
met amplification
met copy number
met protein expression
Metastasis
Neoplasms - blood
Neoplasms - drug therapy
Neoplasms - genetics
Neoplasms - pathology
Neoplastic Cells, Circulating - metabolism
Prospective Studies
Prostate
Protein Kinase Inhibitors - pharmacology
Protein Kinase Inhibitors - therapeutic use
Proteins
Proto-Oncogene Proteins c-met - blood
Proto-Oncogene Proteins c-met - genetics
Retrospective Studies
targeted therapy
Tumor cells
Tumors
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Summary:MET alterations may provide a potential biomarker to evaluate patients who will benefit from treatment with MET inhibitors. Therefore, the purpose of the present study is to investigate the utility of a liquid biopsy-based strategy to assess MET alterations in cancer patients. We analyzed amplification in circulating free DNA (cfDNA) from 174 patients with cancer and 49 healthy controls and demonstrated the accuracy of the analysis to detect its alteration in patients. Importantly, a significant correlation between cfDNA concentration and copy number (CN) in cancer patients ( = 0.57,
ISSN:2073-4409
2073-4409
DOI:10.3390/cells9020522