Natural Products as Anticancer Agents: Current Status and Future Perspectives

Natural products have been an invaluable and useful source of anticancer agents over the years. Several compounds have been synthesized from natural products by modifying their structures or by using naturally occurring compounds as building blocks in the synthesis of these compounds for various pur...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2022-11, Vol.27 (23), p.8367
Main Authors: Naeem, Abid, Hu, Pengyi, Yang, Ming, Zhang, Jing, Liu, Yali, Zhu, Weifeng, Zheng, Qin
Format: Article
Language:English
Subjects:
Alopecia
Angiogenesis
anti-cancer plants
Antimitotic agents
Antineoplastic agents
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Baldness
bioactive anti-tumor agents
Biological Products - chemistry
Biological Products - pharmacology
Biological Products - therapeutic use
Cancer
Cancer therapies
Care and treatment
Cell cycle
chemoprevention
Chemotherapy
Clinical trials
Combinatorial analysis
Cytotoxic agents
Cytotoxicity
Disease prevention
Drug delivery systems
Drug Discovery
Drug resistance
Drugs
Formulations
Humans
Kinases
Medical prognosis
Medical research
Metastasis
Methods
Molecular modelling
Mortality
Natural products
Neoplasms - drug therapy
Neoplasms - prevention & control
phytochemicals
Radiation therapy
Review
Skin cancer
Testing
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Summary:Natural products have been an invaluable and useful source of anticancer agents over the years. Several compounds have been synthesized from natural products by modifying their structures or by using naturally occurring compounds as building blocks in the synthesis of these compounds for various purposes in different fields, such as biology, medicine, and engineering. Multiple modern and costly treatments have been applied to combat cancer and limit its lethality, but the results are not significantly refreshing. Natural products, which are a significant source of new therapeutic drugs, are currently being investigated as potential cytotoxic agents and have shown a positive trend in preclinical research and have prompted numerous innovative strategies in order to combat cancer and expedite the clinical research. Natural products are becoming increasingly important for drug discovery due to their high molecular diversity and novel biofunctionality. Furthermore, natural products can provide superior efficacy and safety due to their unique molecular properties. The objective of the current review is to provide an overview of the emergence of natural products for the treatment and prevention of cancer, such as chemosensitizers, immunotherapeutics, combinatorial therapies with other anticancer drugs, novel formulations of natural products, and the molecular mechanisms underlying their anticancer properties.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27238367