Changes in bispectral index and patient state index during sugammadex reversal of neuromuscular blockade under steady-state sevoflurane anesthesia

• Published in: Scientific reports 2023-03, Vol.13 (1), p.4030-4030, Article 4030
• Main Authors: Kim, Jeayoun, Kim, Doyeon, Kim, Inho, Jeong, Ji Seon
• Format: Article
• Language: English
• Subjects: 692/308/2779; 692/308/2779/109; Anesthesia; Anesthetics; Anesthetics, Intravenous; Electromyography; Humanities and Social Sciences; Humans; multidisciplinary; Neuromuscular Blockade; Science; Science (multidisciplinary); Sevoflurane; Sugammadex
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-023-31025-9

Few studies have investigated the changes in patient state index (PSI) and bispectral index (BIS) in response to abrupt increase in electromyographic (EMG) activity. These were performed using intravenous anesthetics or reversal agents for neuromuscular blockade (NMB) other than sugammadex. We compared the changes in BIS and PSI values caused by the sugammadex reversal of NMB during steady-state sevoflurane anesthesia. We enrolled 50 patients with American Society of Anesthesiologists physical status 1 and 2. At the end of the surgery, we administered 2 mg kg −1 sugammadex while maintaining sevoflurane for a 10-min study period. The changes in BIS and PSI from baseline (T 0 ) to train of four ratio of 90% were not significantly different (median difference 0; 95% CI − 3 to 2; P = 0.83), neither were the changes in BIS and PSI values from T 0 to their maximum values (median difference 1; 95% CI − 1 to 4; P = 0.53). Maximum BIS and PSI were significantly higher than their baseline values (median difference 6; 95% CI 4–9; P