Mast cells are major contributors to the pathophysiology of Graves’ Ophthalmopathy (GO)

Conclusion Mast cells are important in the pathophysiology of GO, as their numbers are increased in GO orbital tissue and their products histamine and tryptase stimulate cytokine and hyaluronan production as well as orbital fibroblast proliferation. [...] mast cells contribute to the orbital inflamm...

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Bibliographic Details
Published in:Journal of translational medicine 2010-11, Vol.8 (S1), p.P22-P22, Article P22
Main Authors: Van Steensel, L, Paridaens, D, van Hagen, P M, Kuijpers, RWAM, Van den Bosch, W A, Drexhage, H A, Hooijkaas, H, Dik, W A
Format: Article
Language:English
Subjects:
Cells
Immunology
Poster Presentation
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Summary:Conclusion Mast cells are important in the pathophysiology of GO, as their numbers are increased in GO orbital tissue and their products histamine and tryptase stimulate cytokine and hyaluronan production as well as orbital fibroblast proliferation. [...] mast cells contribute to the orbital inflammation and tissue expansion typical for GO.
ISSN:1479-5876
1479-5876
DOI:10.1186/1479-5876-8-S1-P22