Synthesis of 2-aminopyridine Lactones and Studies of Their Antioxidant, Antibacterial and Antifungal Properties

In the present work, the synthesis and biological activities of substituted 2-aminopyridine δ-lactone derivatives were achieved. 4,6,6-trimethyl-2-oxo-5,6-dihydro-2H-pyran-3-carbonitrile was synthesised from 4-hydroxy-4-methylpentan-2-one, followed by its transformation in enaminonitrile with DMFDMA...

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Bibliographic Details
Published in:Chemistry Proceedings 2022, Vol.6 (1), p.94
Main Authors: Salhi, Fadila, Cheikh, Nawel, Villemin, Didier, Bar, Nathalie
Format: Article
Language:English
Subjects:
2-aminopyridines
antibacterial activity
antioxidant
bis-2-aminopyridines
Chemical Sciences
DPPH
Medicinal Chemistry
Organic chemistry
radical scavenger
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Summary:In the present work, the synthesis and biological activities of substituted 2-aminopyridine δ-lactone derivatives were achieved. 4,6,6-trimethyl-2-oxo-5,6-dihydro-2H-pyran-3-carbonitrile was synthesised from 4-hydroxy-4-methylpentan-2-one, followed by its transformation in enaminonitrile with DMFDMA. The antioxidant effects of substituted 2-aminopyridine δ-lactone derivatives were evaluated through DPPH assay and revealed a great antioxidant capacity. The antifungal and antibacterial activities were investigated by disc diffusion method against clinical Gram-negative bacteria and against clinical fungi. The study shows moderate to very good antibacterial and antifungal activities for the new substituted 2-aminopyridine δ-lactone derivatives.
ISSN:2673-4583
DOI:10.3390/ecsoc-25-11709