The Influence of Permeability through Bacterial Porins in Whole-Cell Compound Accumulation

The lack of new drugs for Gram-negative pathogens is a global threat to modern medicine. The complexity of their cell envelope, with an additional outer membrane, hinders internal accumulation and thus, the access of molecules to their targets. Our limited understanding of the molecular basis for co...

Full description

Saved in:
Bibliographic Details
Published in:Antibiotics (Basel) 2021-05, Vol.10 (6), p.635
Main Authors: Acosta-Gutiérrez, Silvia, Bodrenko, Igor, Ceccarelli, Matteo
Format: Article
Language:English
Subjects:
Accumulation
Antibacterial materials
Antibiotics
Bacteria
Datasets
E coli
Efflux
Genomics
Gram-negative bacteria
Gram-positive bacteria
Pathogens
Permeability
Permeability coefficient
Porins
RNA polymerase
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The lack of new drugs for Gram-negative pathogens is a global threat to modern medicine. The complexity of their cell envelope, with an additional outer membrane, hinders internal accumulation and thus, the access of molecules to their targets. Our limited understanding of the molecular basis for compound influx and efflux from these pathogens is a major bottleneck for the discovery of effective antibacterial compounds. Here we analyse the correlation between the whole-cell compound accumulation of ~200 molecules and their predicted porin permeability coefficient (influx), using a recently developed scoring function. We found a strong linear relationship (74%) between the two, confirming porins key in compound uptake in Gram-negative bacteria. The analysis of this unique dataset aids to better understand the molecular descriptors behind whole-cell accumulation and molecular uptake in Gram-negative bacteria.
ISSN:2079-6382
2079-6382
DOI:10.3390/antibiotics10060635