Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aphid crop pest Myzus persicae

The aphid Myzus persicae is a destructive agricultural pest that displays an exceptional ability to develop resistance to both natural and synthetic insecticides. To investigate the evolution of resistance in this species we generated a chromosome-scale genome assembly and living panel of >110 fu...

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Bibliographic Details
Published in:Communications biology 2021-07, Vol.4 (1), p.847-16, Article 847
Main Authors: Singh, Kumar Saurabh, Cordeiro, Erick M G, Troczka, Bartlomiej J, Pym, Adam, Mackisack, Joanna, Mathers, Thomas C, Duarte, Ana, Legeai, Fabrice, Robin, Stéphanie, Bielza, Pablo, Burrack, Hannah J, Charaabi, Kamel, Denholm, Ian, Figueroa, Christian C, Ffrench-Constant, Richard H, Jander, Georg, Margaritopoulos, John T, Mazzoni, Emanuele, Nauen, Ralf, Ramírez, Claudio C, Ren, Guangwei, Stepanyan, Ilona, Umina, Paul A, Voronova, Nina V, Vontas, John, Williamson, Martin S, Wilson, Alex C C, Xi-Wu, Gao, Youn, Young-Nam, Zimmer, Christoph T, Simon, Jean-Christophe, Hayward, Alex, Bass, Chris
Format: Article
Language:English
Subjects:
Animals
Aphids - classification
Aphids - genetics
Aphids - physiology
Base Sequence
Evolution, Molecular
Genetic Variation
Genome, Insect - genetics
Genomics - methods
Geography
Host-Parasite Interactions - drug effects
Insecticide Resistance - genetics
Insecticides - pharmacology
Life Sciences
Mutation
Phylogeny
Plants - parasitology
Polymorphism, Single Nucleotide
Sequence Homology, Nucleic Acid
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Summary:The aphid Myzus persicae is a destructive agricultural pest that displays an exceptional ability to develop resistance to both natural and synthetic insecticides. To investigate the evolution of resistance in this species we generated a chromosome-scale genome assembly and living panel of >110 fully sequenced globally sampled clonal lines. Our analyses reveal a remarkable diversity of resistance mutations segregating in global populations of M. persicae. We show that the emergence and spread of these mechanisms is influenced by host-plant associations, uncovering the widespread co-option of a host-plant adaptation that also offers resistance against synthetic insecticides. We identify both the repeated evolution of independent resistance mutations at the same locus, and multiple instances of the evolution of novel resistance mechanisms against key insecticides. Our findings provide fundamental insights into the genomic responses of global insect populations to strong selective forces, and hold practical relevance for the control of pests and parasites.
ISSN:2399-3642
2399-3642
DOI:10.1038/s42003-021-02373-x