Cancer Diagnosis Using a Liquid Biopsy: Challenges and Expectations

The field of cancer diagnostics has recently been impacted by new and exciting developments in the area of liquid biopsy. A liquid biopsy is a minimally invasive alternative to surgical biopsies of solid tissues, typically achieved through the withdrawal of a blood sample or other body fluids, allow...

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Bibliographic Details
Published in:Diagnostics (Basel) 2018-05, Vol.8 (2), p.31
Main Authors: Castro-Giner, Francesc, Gkountela, Sofia, Donato, Cinzia, Alborelli, Ilaria, Quagliata, Luca, Ng, Charlotte K Y, Piscuoglio, Salvatore, Aceto, Nicola
Format: Article
Language:English
Subjects:
Apoptosis
cancer diagnosis
cancer treatment
circulating tumor cells
deep-sequencing
Deoxyribonucleic acid
DNA
Epigenetics
Gangrene
Laboratories
liquid biopsy
Lung cancer
Metastasis
Mutation
Patients
Plasma
Questioning
Review
single cell analysis
Tumors
Urine
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Summary:The field of cancer diagnostics has recently been impacted by new and exciting developments in the area of liquid biopsy. A liquid biopsy is a minimally invasive alternative to surgical biopsies of solid tissues, typically achieved through the withdrawal of a blood sample or other body fluids, allowing the interrogation of tumor-derived material including circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) fragments that are present at a given time point. In this short review, we discuss a few studies that summarize the state-of-the-art in the liquid biopsy field from a diagnostic perspective, and speculate on current challenges and expectations of implementing liquid biopsy testing for cancer diagnosis and monitoring in the clinical setting.
ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics8020031