Prospective Evaluation of the Efficacy of a Food Supplement in Increasing Photoprotection and Improving Selective Markers Related to Skin Photo-Ageing

Introduction Skin exposure to ultraviolet radiation (UVR) can cause oxidative stress, particularly in the absence of adequate protective measures or in individuals with a sensitive skin type. Most commonly, protection from UVR entails the use of topical sunscreens. Sunscreens, however, have various...

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Bibliographic Details
Published in:Dermatology and therapy 2020-02, Vol.10 (1), p.163-178
Main Authors: Granger, Corinne, Aladren, Sonia, Delgado, Jesus, Garre, Aurora, Trullas, Carles, Gilaberte, Yolanda
Format: Article
Language:English
Subjects:
Antioxidant protection
Clinical study
Dermatology
Internal Medicine
Medicine
Medicine & Public Health
Oral and Maxillofacial Surgery
Oral supplement
Original Research
Photoprotection
Plastic Surgery
Quality of Life Research
Sunscreen
Ultraviolet radiation
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Summary:Introduction Skin exposure to ultraviolet radiation (UVR) can cause oxidative stress, particularly in the absence of adequate protective measures or in individuals with a sensitive skin type. Most commonly, protection from UVR entails the use of topical sunscreens. Sunscreens, however, have various limitations. The objective of this study was to evaluate the efficacy and tolerability of an oral food supplement containing a combination of actives with mainly antioxidative properties (vitamins A, C, D3, E, selenium, lycopene, lutein, as well as green tea, polypodium and grape extracts) in the context of photoprotection. Methods Photoprotective efficacy was assessed in a 12-week-long, open, prospective and monocentric clinical study with 30 subjects (27 women and 3 men) having a Fitzpatrick skin type I-III and manifesting clinical ageing signs. The study included several visits (14, 28, 56, and 84 days after starting supplement intake), in which photoprotection was evaluated by the measurement of the minimal erythema dose (MED), while the antioxidant capacity of the skin was assessed through ferric reducing antioxidant power (FRAP) and malondialdehyde (MDA) assays. Additionally, several skin parameters (including radiance, elasticity, and moisture) were evaluated. Product evaluation was performed throughout the length of the study by means of a self-assessment questionnaire, and safety was monitored through a self-recording of all observed adverse reactions. Results The MED levels increased significantly compared to baseline throughout the study visits, reaching an increase of + 8.1% at T84, p  
ISSN:2193-8210
2190-9172
DOI:10.1007/s13555-019-00345-y