Effect of immunology biomarkers associated with hip fracture and fracture risk in older adults

Osteoporosis is a skeletal disease that can increase the risk of fractures, leading to adverse health and socioeconomic consequences. However, current clinical methods have limitations in accurately estimating fracture risk, particularly in older adults. Thus, new technologies are necessary to impro...

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Bibliographic Details
Published in:Immunity & ageing 2023-10, Vol.20 (1), p.1-55, Article 55
Main Authors: Cedeno-Veloz, Bernardo Abel, Lozano-Vicario, Lucía, Zambom-Ferraresi, Fabricio, Fernández-Irigoyen, Joaquín, Santamaría, Enrique, Rodríguez-García, Alba, Romero-Ortuno, Roman, Mondragon-Rubio, Jaime, Ruiz-Ruiz, Javier, Ramírez-Vélez, Robinson, Izquierdo, Mikel, Martínez-Velilla, Nicolás
Format: Article
Language:English
Subjects:
Aged
Biological markers
Biomarkers
Body composition
Body mass index
Bone density
Brief Report
Candidates
Chemokines
Clinical practice guidelines
Colony-stimulating factor
Comparative analysis
Cross-sectional studies
Cytokines
Densitometry
Fractures
FRAX
Hip
Hip fractures
Hip joint
Immune system
Immunology
Innovations
Interleukin 6
Interleukins
Joint surgery
Lymphotoxin
Musculoskeletal system
Older people
Osteoarthritis
Osteoporosis
Pathophysiology
Patients
Prognosis
Protein-tyrosine kinase
Proteins
Proteomics
Rheumatoid arthritis
Risk assessment
Risk factors
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Summary:Osteoporosis is a skeletal disease that can increase the risk of fractures, leading to adverse health and socioeconomic consequences. However, current clinical methods have limitations in accurately estimating fracture risk, particularly in older adults. Thus, new technologies are necessary to improve the accuracy of fracture risk estimation. In this observational study, we aimed to explore the association between serum cytokines and hip fracture status in older adults, and their associations with fracture risk using the FRAX reference tool. We investigated the use of a proximity extension assay (PEA) with Olink. We compared the characteristics of the population, functional status and detailed body composition (determined using densitometry) between groups. We enrolled 40 participants, including 20 with hip fracture and 20 without fracture, and studied 46 cytokines in their serum. After conducting a score plot and two unpaired t-tests using the Benjamini-Hochberg method, we found that Interleukin 6 (IL-6), Lymphotoxin-alpha (LT-α), Fms-related tyrosine kinase 3 ligand (FLT3LG), Colony stimulating factor 1 (CSF1), and Chemokine (C-C motif) ligand 7 (CCL7) were significantly different between fracture and non-fracture patients (p 
ISSN:1742-4933
1742-4933
DOI:10.1186/s12979-023-00379-z