Application of Antiviral Polyoxometalates to Living Environments—Antiviral Moist Hand Towels and Stationery Items

Safe, secure, and environmentally friendly active substances should be developed. VB (virus block) refers to an antibacterial/antiviral mixture of two kinds of polyoxometalates (PMs), i.e., K11H[(VO)3(SbW9O33)2]·27H2O (VB2) and α-Na2[SbW9O33]9− (VB3), and polyhexamethylene biguanide (PHMB). VB was d...

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Bibliographic Details
Published in:Applied sciences 2020-11, Vol.10 (22), p.8246
Main Authors: Dan, Katsuaki, Fujinami, Katsuyuki, Sumitomo, Hajime, Ogiwara, Yasuaki, Suhara, Shigehiko, Konno, Yoshiharu, Sawada, Mitsuhiro, Soga, Yusuke, Takada, Atsushi, Takanashi, Keita, Watanabe, Kenji, Shinozuka, Tatsuo
Format: Article
Language:English
Subjects:
Antiinfectives and antibacterials
Aqueous solutions
Bacillus cereus
Bacteria
Chemical properties
Coronaviruses
Disposable wipes
Experiments
Health aspects
High temperature
Hygiene
Influenza
influenza virus
Materials
MRSA
norovirus
Physiological aspects
Polyhexanide
Polymerase chain reaction
polyoxometalate
Polyoxometallates
Proteins
Reverse transcription
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Staphylococcus infections
Towels
Transition metal compounds
Virus inhibitors
Viruses
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Summary:Safe, secure, and environmentally friendly active substances should be developed. VB (virus block) refers to an antibacterial/antiviral mixture of two kinds of polyoxometalates (PMs), i.e., K11H[(VO)3(SbW9O33)2]·27H2O (VB2) and α-Na2[SbW9O33]9− (VB3), and polyhexamethylene biguanide (PHMB). VB was demonstrated to exert antiviral effects on cultured cells. The effects were maintained even in hygiene products or solids. The antiviral effects were analyzed by reverse transcription–polymerase chain reaction (RT–PCR), and the results were correlated with TCID50, potentially eliminating the need for handling infectious viruses. VB was demonstrated to be extremely effective (up to 99.99% inhibition) in cultured cells, with antibacterial/antiviral effects maintained in VB-containing hygiene products. VB was applied to solids, demonstrating their high applicability and versatility. VB withstands high temperatures regardless of materials because its effects are enhanced by more frequent contact with viruses and bacteria due to the increased surface area of the compound.
ISSN:2076-3417
2076-3417
DOI:10.3390/app10228246