Nonbacterial thrombotic endocarditis as a paraneoplastic manifestation of newly diagnosed splenic large B cell lymphoma

Transthoracic echocardiography revealed small oscillating vegetations on aortic cusps without aortic regurgitation and small vegetations on mitral leaflets with mild mitral regurgitation. Due to the unexplained moderate-to-severe thrombocytopenia, which was refractory to platelet transfusion, a bone...

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Bibliographic Details
Published in:The Kaohsiung journal of medical sciences 2023-06, Vol.39 (6), p.644-645
Main Authors: Wang, Ching‐Yun, Lee, Hsiang‐Chun, Lin, Ren‐Jie, Tsai, Jih‐Jin
Format: Article
Language:English
Subjects:
Blood platelets
Bone marrow
Conflicts of interest
Endocarditis
Endocarditis - diagnosis
Endocarditis - diagnostic imaging
Endocarditis, Non-Infective - pathology
Humans
Infections
Liver diseases
Lymphoma
Lymphoma, Large B-Cell, Diffuse - complications
Lymphoma, Large B-Cell, Diffuse - diagnosis
Non-Hodgkin's lymphomas
Tazobactam
Thrombocytopenia
Tomography
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Summary:Transthoracic echocardiography revealed small oscillating vegetations on aortic cusps without aortic regurgitation and small vegetations on mitral leaflets with mild mitral regurgitation. Due to the unexplained moderate-to-severe thrombocytopenia, which was refractory to platelet transfusion, a bone marrow biopsy revealed a normocellular marrow with myelodysplasia of erythroid and megakaryocyte lineage and a smear result of the increased proportion of plasma cells. [...]we report the first case of the treatment-naïve splenic large B cell lymphoma with NBTE as the paraneoplastic manifestation.
ISSN:1607-551X
2410-8650
DOI:10.1002/kjm2.12677