Comparison of survival between dialysis patients with incident high-flux hemodialysis versus on-line hemodiafiltration : a single center experience in Saudi Arabia

Conventional hemodialysis (HD) is the most common treatment modality used for renal replacement therapy. The concept of HD is based on the diffusion of solutes across a semipermeable membrane. Hemofiltration (HF) is based on convective transport of solutes; hemodiafiltration (HDF) is based on combin...

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Bibliographic Details
Published in:Saudi journal of kidney diseases and transplantation 2018, Vol.29 (1), p.107-113
Main Authors: al-Furayyih, Uthman I., Rashwan, Muhammad, Abd al-Salam, Muhammad Said, al-Thaf, Muhammad Mahdi, Ibrahim, Ihab A., al-kurbi, Lutfi A.
Format: Article
Language:English
Subjects:
Age
Analysis
Care and treatment
Chronic kidney failure
Clinical outcomes
Comorbidity
Comparative analysis
Diabetes
Health aspects
Hemodialysis
Hemodialysis patients
Hemofiltration
Hospitals
Hypertension
Internal medicine
Medicine
Mortality
Nephrology
Patient outcomes
Patients
Research centers
Transplants & implants
Treatment outcome
الترشيح
الدم
المرضى
علم المداواة
غسيل الكلى
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Summary:Conventional hemodialysis (HD) is the most common treatment modality used for renal replacement therapy. The concept of HD is based on the diffusion of solutes across a semipermeable membrane. Hemofiltration (HF) is based on convective transport of solutes; hemodiafiltration (HDF) is based on combined convective and diffusive therapies. Data about survival benefit of on-line HDF (OL-HDF) over high-flux HD (HF-HD) is conflicting. We conducted this study to investigate if there is a survival difference between the two treatment modalities. This study is a retrospective, single-center study in which 78 patients were screened; 18 were excluded and 60 patients were analyzed. The study patients were aged 47.5 ± 20.7 years, 33 patients (55%) were on HF-HD, and 27 patients (45%) were on OL-HDF. A total of 24 patients (40%) of both groups were diabetic and, the mean duration on dialysis was 43.5 ± 21.3 months in the HF-HD group and 41.2 ± 22.0 months in the OL-HDF group. The mean substitution volume for OL-HDF was 22.3 ± 2.5 L. Survival was 73% [95%, confidence interval (CI) 60–84] in the HF-HD group and 65% (95%, CI 54–75) in the OL-HDF group by the end of the study period. The unadjusted hazard ratio (HR) with 95% CI comparing HF-HD to high-volume postdilution OL-HDF
ISSN:1319-2442
2320-3838
DOI:10.4103/1319-2442.225191