Advanced Oxidation Processes in Pharmaceutical Formulations: Photo-Fenton Degradation of Peptides and Proteins

Formulations of therapeutic proteins are sensitive to photo-degradation by near UV and visible light. Mechanistically, especially the processes leading to protein modification under visible light exposure are not understood. Potentially, these processes may be triggered by a ligand to metal charge t...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-07, Vol.23 (15), p.8262
Main Author: Schöneich, Christian
Format: Article
Language:English
Subjects:
Amino acids
Aqueous solutions
Charge transfer
Decomposition
Fenton reaction
Light
Manufacturing
Oxidation
peptide
Peptides
Pharmaceuticals
photo-degradation
Photodegradation
Proteins
radicals
Review
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Summary:Formulations of therapeutic proteins are sensitive to photo-degradation by near UV and visible light. Mechanistically, especially the processes leading to protein modification under visible light exposure are not understood. Potentially, these processes may be triggered by a ligand to metal charge transfer in excipient-metal complexes. This article summarizes recent analytical and mechanistic work on such reactions under experimental conditions relevant to pharmaceutical formulations.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23158262