Identification of Poliovirus Receptor-like 3 Protein as a Prognostic Factor in Triple-Negative Breast Cancer

Triple-negative breast cancer (TNBC) represents an aggressive subtype of breast cancer, with a bad prognosis and lack of targeted therapeutic options. Characterized by the absence of estrogen receptors, progesterone receptors, and HER2 expression, TNBC is often associated with a significantly lower...

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Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2024-08, Vol.13 (15), p.1299
Main Authors: Leone, Gian Marco, Mangano, Katia, Caponnetto, Salvatore, Fagone, Paolo, Nicoletti, Ferdinando
Format: Article
Language:English
Subjects:
biomarker
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Breast cancer
Cancer
Cancer therapies
Cell Line, Tumor
Cells
Chemotherapy
Comparative analysis
Development and progression
Enhancer of Zeste Homolog 2 Protein - genetics
Enhancer of Zeste Homolog 2 Protein - metabolism
Epidermal growth factor
Epigenetic inheritance
Epigenetics
ErbB-2 protein
Estrogen
Estrogen receptors
Estrogens
EZH2
Female
Gene Expression Regulation, Neoplastic
Genes
Humans
immune checkpoint
Medical prognosis
Metabolism
Metastasis
Molecular modelling
Nectins - genetics
Nectins - metabolism
Neomycin
Oncology, Experimental
Poliovirus
Progesterone
Progesterone receptors
Prognosis
PVRL3
Reagents
Scientific equipment and supplies industry
Software
Survival analysis
Transcriptomics
Triple Negative Breast Neoplasms - genetics
Triple Negative Breast Neoplasms - metabolism
Triple Negative Breast Neoplasms - pathology
triple-negative breast cancer
Tumor cell lines
Tumors
Vorinostat
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Description
Summary:Triple-negative breast cancer (TNBC) represents an aggressive subtype of breast cancer, with a bad prognosis and lack of targeted therapeutic options. Characterized by the absence of estrogen receptors, progesterone receptors, and HER2 expression, TNBC is often associated with a significantly lower survival rate compared to other breast cancer subtypes. Our study aimed to explore the prognostic significance of 83 immune-related genes, by using transcriptomic data from the TCGA database. Our analysis identified the Poliovirus Receptor-Like 3 protein (PVRL3) as a critical negative prognostic marker in TNBC patients. Furthermore, we found that the Enhancer of Zeste Homolog 2 (EZH2), a well-known epigenetic regulator, plays a pivotal role in modulating PVRL3 levels in TNBC cancer cell lines expressing EZH2 along with high levels of PVRL3. The elucidation of the EZH2-PVRL3 regulatory axis provides valuable insights into the molecular mechanisms underlying TNBC aggressiveness and opens up potential pathways for personalized therapeutic intervention.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells13151299