Determining key clinical predictors for chronic ankle instability and return to sports with cost of illness analysis: protocol of a prospective cohort study

IntroductionAnkle sprains are common in sports and the general population. Although considered innocuous, a large proportion has residual complaints such as recurrent ankle sprains and develop chronic ankle instability. Although some predicting factors are identified, there is no unequivocality rega...

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Bibliographic Details
Published in:BMJ open 2023-05, Vol.13 (5), p.e069867-e069867
Main Authors: Wagemans, Jente, Taeymans, Jan, Kuppens, Kevin, Baur, Heiner, Bleakley, Chris, Vissers, Dirk
Format: Article
Language:English
Subjects:
Adult
Ankle
Ankle Injuries - complications
Athletic recruitment
Cohort analysis
Consortia
Cost of Illness
Costs
Decision making
Feasibility studies
foot & ankle
Football
health economics
Humans
Illnesses
Joint Instability - complications
Muscle strength
musculoskeletal disorders
Patients
Prospective Studies
Rehabilitation
Rehabilitation Medicine
Return to Sport
School dropouts
Sprains and Strains
Systematic review
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Summary:IntroductionAnkle sprains are common in sports and the general population. Although considered innocuous, a large proportion has residual complaints such as recurrent ankle sprains and develop chronic ankle instability. Although some predicting factors are identified, there is no unequivocality regarding the development of chronic ankle instability, nor about the optimal rehabilitation for an acute ankle sprain. Alongside the biomechanical impairments, ankle sprains are a burden on society due to substantial economic costs. Therefore, we aim to identify key clinical predictors of chronic ankle instability or recovery after acute lateral ankle sprain. Additionally, we aim to determine cost-of-illness of patients who developed chronic ankle instability.Methods and analysisThis prospective cohort study (Clinicaltrials.gov: NCT05637008 - pre-results) aims to recruit adult (18–55 years) patients with an acute lateral ankle sprain who are active in sports. Clinical assessments and patient-reported outcome measures will be used to collect data at 7–14 days, 6 weeks, 12 weeks and 12 months after enrolment in the study. The primary outcome will be chronic ankle instability at 12-month follow-up. Salient outcomes will be analysed by logistic regression to determine association with the development of chronic ankle instability. Participants will fill in a cost diary containing direct and indirect costs related to their injury.Ethics and disseminationsThe ethical committee of the Antwerp University Hospital (B3002022000138) has given approval of the protocol and consent forms on 10 October 2022. We perform this study according to the Helsinki Declaration. We will present results at conferences or webinars and publish in peer-reviewed articles.NCT05637008.
ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2022-069867