Experimental comparative study of a novel drug-eluting arteriovenous graft in a sheep model

Arteriovenous (AV) grafts often develop severe complications of stenosis due to neointimal proliferation that occurs either at the venous anastomosis site or at the outflow receiving vein. This study compares primary patency during 12 months of follow up for a new experimental Biomodics interpenetra...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in cardiovascular medicine 2024-02, Vol.11, p.1341154-1341154
Main Authors: Riber, Sara Schødt, Clausen, Lene Langhoff, Dahl, Marie, Riber, Lars Peter Schødt, Andersen, Thomas Emil, Lindholt, Jes S
Format: Article
Language:English
Subjects:
Cardiovascular Medicine
expanded PTFE
experimental animal models
innovativeness
surgical
vascular surgical procedures
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c418t-82c3012eeb728f6a0e68642a13e1bb575c6a9f0a31e0161229b6a498e531149d3
container_end_page 1341154
container_issue
container_start_page 1341154
container_title Frontiers in cardiovascular medicine
container_volume 11
creator Riber, Sara Schødt
Clausen, Lene Langhoff
Dahl, Marie
Riber, Lars Peter Schødt
Andersen, Thomas Emil
Lindholt, Jes S
description Arteriovenous (AV) grafts often develop severe complications of stenosis due to neointimal proliferation that occurs either at the venous anastomosis site or at the outflow receiving vein. This study compares primary patency during 12 months of follow up for a new experimental Biomodics interpenetrating polymer network (IPN) drug-eluting graft prototype with state-of-the-art GORE® ACUSEAL (ACUSEAL) in an AV graft model in sheep. An end-to-end bypass from the common carotid artery to the jugularis vein was performed bilaterally in 12 sheep. The usage of ACUSEAL or the IPN, both 6.0 mm in diameter, was determined via randomization. The sheep were followed up every 4 weeks with ultrasonic duplex scanning to determine patency; the experienced observer was blinded to the randomization. One sheep died after 11 days, and the final sample accordingly consisted of 11 animals. When comparing neointimal hyperplasia after 12 months in the two grafts, Fisher's exact test showed a significant difference with none out of 11 in the IPN grafts and 9 out of 11 in the ACUSEAL graft (  
doi_str_mv 10.3389/fcvm.2024.1341154
format article
fullrecord <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_8a94d147c48f40b89696534b8c89f436</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_8a94d147c48f40b89696534b8c89f436</doaj_id><sourcerecordid>2956160729</sourcerecordid><originalsourceid>FETCH-LOGICAL-c418t-82c3012eeb728f6a0e68642a13e1bb575c6a9f0a31e0161229b6a498e531149d3</originalsourceid><addsrcrecordid>eNpVkU9v1DAQxS0EolXpB-CCfOSSxf9jnxCqClSqxAUkJA6W44zTVE4c7GRFvz1edqnak63xez_PzEPoLSU7zrX5EPx-2jHCxI5yQakUL9A5Y6ZtiJQ_Xz65n6HLUu4JIVWjpdKv0RnXQumWkXP06_rPAnmcYF5dxD5Ni8tuHfeAy7r1DzgF7PCc9hBxn7ehgbit4zxgl9dqq_U5bQUP2YUVj3PVljuABU-ph_gGvQouFrg8nRfox-fr71dfm9tvX26uPt02XlC9Npp5TigD6Fqmg3IElFaCOcqBdp1spVfOBOI4BUIVrXN1ygmjQXJKhen5Bbo5cvvk7u1Sp3H5wSY32n-FlAdb2x19BKudET0VrRc6CNJpo4ySXHTaaxMEV5X18chatm6C3te9ZBefQZ-_zOOdHdLeUmKY1K2ohPcnQk6_NyirncbiIUY3Q92VZUYqqkjLTJXSo9TnVEqG8PgPJfYQsj2EbA8h21PI1fPuaYOPjv-R8r8Yw6O2</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2956160729</pqid></control><display><type>article</type><title>Experimental comparative study of a novel drug-eluting arteriovenous graft in a sheep model</title><source>PubMed Central</source><creator>Riber, Sara Schødt ; Clausen, Lene Langhoff ; Dahl, Marie ; Riber, Lars Peter Schødt ; Andersen, Thomas Emil ; Lindholt, Jes S</creator><creatorcontrib>Riber, Sara Schødt ; Clausen, Lene Langhoff ; Dahl, Marie ; Riber, Lars Peter Schødt ; Andersen, Thomas Emil ; Lindholt, Jes S</creatorcontrib><description>Arteriovenous (AV) grafts often develop severe complications of stenosis due to neointimal proliferation that occurs either at the venous anastomosis site or at the outflow receiving vein. This study compares primary patency during 12 months of follow up for a new experimental Biomodics interpenetrating polymer network (IPN) drug-eluting graft prototype with state-of-the-art GORE® ACUSEAL (ACUSEAL) in an AV graft model in sheep. An end-to-end bypass from the common carotid artery to the jugularis vein was performed bilaterally in 12 sheep. The usage of ACUSEAL or the IPN, both 6.0 mm in diameter, was determined via randomization. The sheep were followed up every 4 weeks with ultrasonic duplex scanning to determine patency; the experienced observer was blinded to the randomization. One sheep died after 11 days, and the final sample accordingly consisted of 11 animals. When comparing neointimal hyperplasia after 12 months in the two grafts, Fisher's exact test showed a significant difference with none out of 11 in the IPN grafts and 9 out of 11 in the ACUSEAL graft (  &lt; 0.001). However, the Biomodics IPN exhibited severe deterioration over time. Almost all of the grafts occluded during the 12 months of follow up. Although the zwitterion-bounded interpenetrating drug eluting polymer network showed signs to impair neointimal hyperplasia and thrombosis, age-related degeneration hindered demonstrating a potential improvement in patency.</description><identifier>ISSN: 2297-055X</identifier><identifier>EISSN: 2297-055X</identifier><identifier>DOI: 10.3389/fcvm.2024.1341154</identifier><identifier>PMID: 38468720</identifier><language>eng</language><publisher>Switzerland: Frontiers Media S.A</publisher><subject>Cardiovascular Medicine ; expanded PTFE ; experimental animal models ; innovativeness ; surgical ; vascular surgical procedures</subject><ispartof>Frontiers in cardiovascular medicine, 2024-02, Vol.11, p.1341154-1341154</ispartof><rights>2024 Riber, Clausen, Dahl, Riber, Andersen and Lindholt.</rights><rights>2024 Riber, Clausen, Dahl, Riber, Andersen and Lindholt. 2024 Schødt Riber, Clausen, Dahl, Riber, Andersen and Lindholt</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c418t-82c3012eeb728f6a0e68642a13e1bb575c6a9f0a31e0161229b6a498e531149d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10925874/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10925874/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38468720$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Riber, Sara Schødt</creatorcontrib><creatorcontrib>Clausen, Lene Langhoff</creatorcontrib><creatorcontrib>Dahl, Marie</creatorcontrib><creatorcontrib>Riber, Lars Peter Schødt</creatorcontrib><creatorcontrib>Andersen, Thomas Emil</creatorcontrib><creatorcontrib>Lindholt, Jes S</creatorcontrib><title>Experimental comparative study of a novel drug-eluting arteriovenous graft in a sheep model</title><title>Frontiers in cardiovascular medicine</title><addtitle>Front Cardiovasc Med</addtitle><description>Arteriovenous (AV) grafts often develop severe complications of stenosis due to neointimal proliferation that occurs either at the venous anastomosis site or at the outflow receiving vein. This study compares primary patency during 12 months of follow up for a new experimental Biomodics interpenetrating polymer network (IPN) drug-eluting graft prototype with state-of-the-art GORE® ACUSEAL (ACUSEAL) in an AV graft model in sheep. An end-to-end bypass from the common carotid artery to the jugularis vein was performed bilaterally in 12 sheep. The usage of ACUSEAL or the IPN, both 6.0 mm in diameter, was determined via randomization. The sheep were followed up every 4 weeks with ultrasonic duplex scanning to determine patency; the experienced observer was blinded to the randomization. One sheep died after 11 days, and the final sample accordingly consisted of 11 animals. When comparing neointimal hyperplasia after 12 months in the two grafts, Fisher's exact test showed a significant difference with none out of 11 in the IPN grafts and 9 out of 11 in the ACUSEAL graft (  &lt; 0.001). However, the Biomodics IPN exhibited severe deterioration over time. Almost all of the grafts occluded during the 12 months of follow up. Although the zwitterion-bounded interpenetrating drug eluting polymer network showed signs to impair neointimal hyperplasia and thrombosis, age-related degeneration hindered demonstrating a potential improvement in patency.</description><subject>Cardiovascular Medicine</subject><subject>expanded PTFE</subject><subject>experimental animal models</subject><subject>innovativeness</subject><subject>surgical</subject><subject>vascular surgical procedures</subject><issn>2297-055X</issn><issn>2297-055X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpVkU9v1DAQxS0EolXpB-CCfOSSxf9jnxCqClSqxAUkJA6W44zTVE4c7GRFvz1edqnak63xez_PzEPoLSU7zrX5EPx-2jHCxI5yQakUL9A5Y6ZtiJQ_Xz65n6HLUu4JIVWjpdKv0RnXQumWkXP06_rPAnmcYF5dxD5Ni8tuHfeAy7r1DzgF7PCc9hBxn7ehgbit4zxgl9dqq_U5bQUP2YUVj3PVljuABU-ph_gGvQouFrg8nRfox-fr71dfm9tvX26uPt02XlC9Npp5TigD6Fqmg3IElFaCOcqBdp1spVfOBOI4BUIVrXN1ygmjQXJKhen5Bbo5cvvk7u1Sp3H5wSY32n-FlAdb2x19BKudET0VrRc6CNJpo4ySXHTaaxMEV5X18chatm6C3te9ZBefQZ-_zOOdHdLeUmKY1K2ohPcnQk6_NyirncbiIUY3Q92VZUYqqkjLTJXSo9TnVEqG8PgPJfYQsj2EbA8h21PI1fPuaYOPjv-R8r8Yw6O2</recordid><startdate>20240226</startdate><enddate>20240226</enddate><creator>Riber, Sara Schødt</creator><creator>Clausen, Lene Langhoff</creator><creator>Dahl, Marie</creator><creator>Riber, Lars Peter Schødt</creator><creator>Andersen, Thomas Emil</creator><creator>Lindholt, Jes S</creator><general>Frontiers Media S.A</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20240226</creationdate><title>Experimental comparative study of a novel drug-eluting arteriovenous graft in a sheep model</title><author>Riber, Sara Schødt ; Clausen, Lene Langhoff ; Dahl, Marie ; Riber, Lars Peter Schødt ; Andersen, Thomas Emil ; Lindholt, Jes S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-82c3012eeb728f6a0e68642a13e1bb575c6a9f0a31e0161229b6a498e531149d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Cardiovascular Medicine</topic><topic>expanded PTFE</topic><topic>experimental animal models</topic><topic>innovativeness</topic><topic>surgical</topic><topic>vascular surgical procedures</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Riber, Sara Schødt</creatorcontrib><creatorcontrib>Clausen, Lene Langhoff</creatorcontrib><creatorcontrib>Dahl, Marie</creatorcontrib><creatorcontrib>Riber, Lars Peter Schødt</creatorcontrib><creatorcontrib>Andersen, Thomas Emil</creatorcontrib><creatorcontrib>Lindholt, Jes S</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Frontiers in cardiovascular medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Riber, Sara Schødt</au><au>Clausen, Lene Langhoff</au><au>Dahl, Marie</au><au>Riber, Lars Peter Schødt</au><au>Andersen, Thomas Emil</au><au>Lindholt, Jes S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimental comparative study of a novel drug-eluting arteriovenous graft in a sheep model</atitle><jtitle>Frontiers in cardiovascular medicine</jtitle><addtitle>Front Cardiovasc Med</addtitle><date>2024-02-26</date><risdate>2024</risdate><volume>11</volume><spage>1341154</spage><epage>1341154</epage><pages>1341154-1341154</pages><issn>2297-055X</issn><eissn>2297-055X</eissn><abstract>Arteriovenous (AV) grafts often develop severe complications of stenosis due to neointimal proliferation that occurs either at the venous anastomosis site or at the outflow receiving vein. This study compares primary patency during 12 months of follow up for a new experimental Biomodics interpenetrating polymer network (IPN) drug-eluting graft prototype with state-of-the-art GORE® ACUSEAL (ACUSEAL) in an AV graft model in sheep. An end-to-end bypass from the common carotid artery to the jugularis vein was performed bilaterally in 12 sheep. The usage of ACUSEAL or the IPN, both 6.0 mm in diameter, was determined via randomization. The sheep were followed up every 4 weeks with ultrasonic duplex scanning to determine patency; the experienced observer was blinded to the randomization. One sheep died after 11 days, and the final sample accordingly consisted of 11 animals. When comparing neointimal hyperplasia after 12 months in the two grafts, Fisher's exact test showed a significant difference with none out of 11 in the IPN grafts and 9 out of 11 in the ACUSEAL graft (  &lt; 0.001). However, the Biomodics IPN exhibited severe deterioration over time. Almost all of the grafts occluded during the 12 months of follow up. Although the zwitterion-bounded interpenetrating drug eluting polymer network showed signs to impair neointimal hyperplasia and thrombosis, age-related degeneration hindered demonstrating a potential improvement in patency.</abstract><cop>Switzerland</cop><pub>Frontiers Media S.A</pub><pmid>38468720</pmid><doi>10.3389/fcvm.2024.1341154</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2297-055X
ispartof Frontiers in cardiovascular medicine, 2024-02, Vol.11, p.1341154-1341154
issn 2297-055X
2297-055X
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_8a94d147c48f40b89696534b8c89f436
source PubMed Central
subjects Cardiovascular Medicine
expanded PTFE
experimental animal models
innovativeness
surgical
vascular surgical procedures
title Experimental comparative study of a novel drug-eluting arteriovenous graft in a sheep model
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T07%3A43%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Experimental%20comparative%20study%20of%20a%20novel%20drug-eluting%20arteriovenous%20graft%20in%20a%20sheep%20model&rft.jtitle=Frontiers%20in%20cardiovascular%20medicine&rft.au=Riber,%20Sara%20Sch%C3%B8dt&rft.date=2024-02-26&rft.volume=11&rft.spage=1341154&rft.epage=1341154&rft.pages=1341154-1341154&rft.issn=2297-055X&rft.eissn=2297-055X&rft_id=info:doi/10.3389/fcvm.2024.1341154&rft_dat=%3Cproquest_doaj_%3E2956160729%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c418t-82c3012eeb728f6a0e68642a13e1bb575c6a9f0a31e0161229b6a498e531149d3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2956160729&rft_id=info:pmid/38468720&rfr_iscdi=true