In Vitro Synergy of Levofloxacin Plus Piperacillin/Tazobactam against Pseudomonas aeruginosa

In vitro synergy testing using levofloxacin (LVX) plus piperacillin/tazobactam (TZP) was performed by Etest and time-kill assay (TKA) for 31 unique fluoroquinolone-resistant Pseudomonas aeruginosa isolates. The Etest method showed synergy for 9/31 (29%) of isolates, while TKA showed synergy with 14/...

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Bibliographic Details
Published in:Interdisciplinary Perspectives on Infectious Diseases 2009-01, Vol.2009 (2009), p.257-261
Main Authors: Chachanidze, Vladimir, Curbelo-Irizarry, Aixa, Ashcraft, Deborah, Pankey, George
Format: Article
Language:English
Subjects:
Pseudomonas aeruginosa
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Summary:In vitro synergy testing using levofloxacin (LVX) plus piperacillin/tazobactam (TZP) was performed by Etest and time-kill assay (TKA) for 31 unique fluoroquinolone-resistant Pseudomonas aeruginosa isolates. The Etest method showed synergy for 9/31 (29%) of isolates, while TKA showed synergy with 14/31 (45%) of isolates. When comparing the Etest method and TKA, concordant results for synergy, antagonism, and indifference were obtained for 24/31 (77%) of the isolates tested.
ISSN:1687-708X
1687-7098
DOI:10.1155/2009/984934