Mean platelet volume/platelet count ratio in combination with tumor markers in colorectal cancer: a retrospective clinical study

Mean platelet volume (MPV) is a marker of platelet activation, which is usually negatively correlated with platelet count (PC). The ratio of MPV to PC (MPV/PC) has an essential role in the diagnosis of multiple malignancies. However, only a few studies investigated the value of MPV/PC in colorectal...

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Bibliographic Details
Published in:BMC cancer 2023-02, Vol.23 (1), p.124-124, Article 124
Main Authors: Zhang, Huan, Lin, Fan, Wang, Zhuocai
Format: Article
Language:English
Subjects:
Age
Analysis
Anticoagulants
Antigens
Biomarkers
Biomarkers, Tumor
Blood
Blood cell count
Blood platelets
Cancer
Cancer therapies
Care and treatment
Clinical medicine
Clinical trials
Colon cancer
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - diagnosis
Combined detection
Diagnosis
Health aspects
Hospitals
Humans
Kruskal-Wallis test
Lymph nodes
Lymphatic metastasis
Lymphatic system
Malignancy
Mean Platelet Volume
Mean platelet volume/platelet count ratio
Metastases
Metastasis
Oncology, Experimental
Peripheral blood
Platelet Count
Platelets
Polyps
Prevention
Retrospective Studies
Risk factors
Software
Theater
Tumor markers
Tumors
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Summary:Mean platelet volume (MPV) is a marker of platelet activation, which is usually negatively correlated with platelet count (PC). The ratio of MPV to PC (MPV/PC) has an essential role in the diagnosis of multiple malignancies. However, only a few studies investigated the value of MPV/PC in colorectal cancer (CRC) and the combination of MPV/PC with tumor markers in CRC. This retrospective clinical study aimed to evaluate the diagnostic value of MPV/PC and tumor markers (CA72-4, CA125, CA199) used alone or in combination in CRC. 200 patients with CRC and 317 patients with colorectal benign polypus pathologically diagnosed during 2019/01/04 to 2022/06/30 were included. Hematological and pathological parameters of the above patients were collected, data were analyzed with Student's t-test, one-way ANOVA or Kruskal-Wallis H test and receiver operating characteristic (ROC) curve, and ROC curve was used to evaluate the diagnostic value of tumor markers and MPV/PC used alone or in combination in CRC. The MPV/PC in CRC group was significantly lower than the control group (P 
ISSN:1471-2407
1471-2407
DOI:10.1186/s12885-023-10585-z