The Effect of Low HBV-DNA Viral Load on Recurrence in Hepatocellular Carcinoma Patients Who Underwent Primary Locoregional Treatment and the Development of a Nomogram Prediction Model

(1) Background: HBV-DNA is an essential clinical indicator of primary hepatocellular carcinoma (HCC) prognosis. Our study aimed to investigate the prognostic implication of a low load of HBV-DNA in HCC patients who underwent local treatment. Additionally, we developed and validated a nomogram to pre...

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Bibliographic Details
Published in:Microorganisms (Basel) 2024-05, Vol.12 (5), p.976
Main Authors: Xiong, Yiqi, Wang, Ziling, Liu, Jiajun, Li, Kang, Zhang, Yonghong
Format: Article
Language:English
Subjects:
Ablation
Blood
Cancer
Cancer therapies
Chemoembolization
Deoxyribonucleic acid
DNA
HBV-DNA
Hepatectomy
Hepatitis B
Hepatitis B virus
Hepatocellular carcinoma
Hepatoma
Liver cancer
Liver cirrhosis
Liver transplants
Local anesthesia
Lymphocytes
Magnetic resonance imaging
Measurement
Medical prognosis
nomogram
Nomograms
Oncology, Experimental
Patients
Performance prediction
Polyvinyl alcohol
Prediction models
Prognosis
recurrence
Regression analysis
Risk factors
Risk groups
Statistical analysis
TACE
Tumors
Veins & arteries
Viremia
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Summary:(1) Background: HBV-DNA is an essential clinical indicator of primary hepatocellular carcinoma (HCC) prognosis. Our study aimed to investigate the prognostic implication of a low load of HBV-DNA in HCC patients who underwent local treatment. Additionally, we developed and validated a nomogram to predict the recurrence of patients with low (20-100 IU/mL) viral loads (L-VL). (2) Methods: A total of 475 HBV-HCC patients were enrolled, including 403 L-VL patients and 72 patients with very low (
ISSN:2076-2607
2076-2607
DOI:10.3390/microorganisms12050976