Clinicopathologic characteristics, outcomes, and prognostic factors of angioimmunoblastic T‐cell lymphoma in China

Background This study aimed to better characterize the clinicopathologic characteristics, outcomes, and prognostic factors of AITL in China. Methods We retrospectively analyzed 312 patients with AITL enrolled between January 2011 and December 2020 from five institutions in China. Results The median...

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Bibliographic Details
Published in:Cancer medicine (Malden, MA) MA), 2023-02, Vol.12 (4), p.3987-3998
Main Authors: Wei, Chong, Li, Wei, Qin, Liping, Liu, Shan, Xue, Chang, Ren, Kexing, Zhang, Zirong, Liu, Caili, Bao, Fang, Zhang, Huilai, Zhou, Hui, Li, Zhiming, Wu, Huijing, Zou, Liqun, Liu, Lihong, Jing, Hongmei, Zhang, Wei
Format: Article
Language:English
Subjects:
Age
Aged
Anemia
angioimmunoblastic T‐cell lymphoma
Anthracycline
Anthracyclines - therapeutic use
Autografts
Bone marrow
Classification
Dehydrogenases
Epstein-Barr virus
Etoposide
Gene expression
Hematopoietic Stem Cell Transplantation
Hepatitis
Humans
Hypergammaglobulinemia
Immunoblastic Lymphadenopathy - therapy
Laboratories
Lymphocytes T
Lymphoma
Lymphoma, T-Cell, Peripheral
Medical prognosis
Multivariate analysis
overall survival
Patients
Prognosis
prognostic factor
prognostic model
Remission
Remission (Medicine)
Retrospective Studies
Risk groups
Spleen
Stem cell transplantation
T-cell lymphoma
Tomography
Transplantation, Autologous
treatment
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Summary:Background This study aimed to better characterize the clinicopathologic characteristics, outcomes, and prognostic factors of AITL in China. Methods We retrospectively analyzed 312 patients with AITL enrolled between January 2011 and December 2020 from five institutions in China. Results The median age was 65 years, with 92.6% advanced stage, 59.7% elevated LDH, 46.1% anemia, and 44.0% hypergammaglobulinemia. The majority of patients (84.9%) received anthracycline‐based regimens with or without etoposide, and only 6.1% underwent autologous stem cell transplantation following first remission. The 5‐year OS and PFS estimates were 43.4% and 25.0% with no significant improvement of survival between patients treated during 2011–2015 and 2016–2020, respectively. Both the International Prognostic Index (IPI) and the prognostic index for PTCL, not otherwise specified (PIT), were predictive for OS. In multivariate analysis, age >70 years, elevated LDH, and albumin level
ISSN:2045-7634
2045-7634
DOI:10.1002/cam4.5248