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Neurofibromin 1 regulates early developmental sleep in Drosophila
Sleep disturbances are common in neurodevelopmental disorders, but knowledge of molecular factors that govern sleep in young animals is lacking. Evidence across species, including , suggests that juvenile sleep has distinct functions and regulatory mechanisms in comparison to sleep in maturity. In f...
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| Published in: | Neurobiology of sleep and circadian rhythms 2023-11, Vol.15, p.100101, Article 100101 |
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| Main Authors: | , , , , , , |
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| container_start_page | 100101 |
| container_title | Neurobiology of sleep and circadian rhythms |
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| creator | Durkin, Jaclyn Poe, Amy R Belfer, Samuel J Rodriguez, Anyara Tang, Si Hao Walker, James A Kayser, Matthew S |
| description | Sleep disturbances are common in neurodevelopmental disorders, but knowledge of molecular factors that govern sleep in young animals is lacking. Evidence across species, including
, suggests that juvenile sleep has distinct functions and regulatory mechanisms in comparison to sleep in maturity. In flies, manipulation of most known adult sleep regulatory genes is not associated with sleep phenotypes during early developmental (larval) stages. Here, we examine the role of the neurodevelopmental disorder-associated gene
(
) in sleep during numerous developmental periods. Mutations in
(
) are associated with sleep and circadian disorders in humans and adult flies. We find in flies that
acts to regulate sleep across the lifespan, beginning during larval stages.
is required in neurons for this function, as is signaling via the Alk pathway. These findings identify
as one of a small number of genes positioned to regulate sleep across developmental periods. |
| doi_str_mv | 10.1016/j.nbscr.2023.100101 |
| format | article |
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, suggests that juvenile sleep has distinct functions and regulatory mechanisms in comparison to sleep in maturity. In flies, manipulation of most known adult sleep regulatory genes is not associated with sleep phenotypes during early developmental (larval) stages. Here, we examine the role of the neurodevelopmental disorder-associated gene
(
) in sleep during numerous developmental periods. Mutations in
(
) are associated with sleep and circadian disorders in humans and adult flies. We find in flies that
acts to regulate sleep across the lifespan, beginning during larval stages.
is required in neurons for this function, as is signaling via the Alk pathway. These findings identify
as one of a small number of genes positioned to regulate sleep across developmental periods.</description><identifier>ISSN: 2451-9944</identifier><identifier>EISSN: 2451-9944</identifier><identifier>DOI: 10.1016/j.nbscr.2023.100101</identifier><identifier>PMID: 37593040</identifier><language>eng</language><publisher>United States: Elsevier</publisher><subject>Autism ; Development ; Drosophila ; Larvae ; Neurofibromatosis ; Research Paper ; Sleep</subject><ispartof>Neurobiology of sleep and circadian rhythms, 2023-11, Vol.15, p.100101, Article 100101</ispartof><rights>2023 The Authors.</rights><rights>2023 The Authors 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3871-85eb9ec368519c844c75238513541f096499219813b011ff8409404ca73010653</citedby><cites>FETCH-LOGICAL-c3871-85eb9ec368519c844c75238513541f096499219813b011ff8409404ca73010653</cites><orcidid>0000-0003-2359-4967</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10428071/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10428071/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37593040$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Durkin, Jaclyn</creatorcontrib><creatorcontrib>Poe, Amy R</creatorcontrib><creatorcontrib>Belfer, Samuel J</creatorcontrib><creatorcontrib>Rodriguez, Anyara</creatorcontrib><creatorcontrib>Tang, Si Hao</creatorcontrib><creatorcontrib>Walker, James A</creatorcontrib><creatorcontrib>Kayser, Matthew S</creatorcontrib><title>Neurofibromin 1 regulates early developmental sleep in Drosophila</title><title>Neurobiology of sleep and circadian rhythms</title><addtitle>Neurobiol Sleep Circadian Rhythms</addtitle><description>Sleep disturbances are common in neurodevelopmental disorders, but knowledge of molecular factors that govern sleep in young animals is lacking. Evidence across species, including
, suggests that juvenile sleep has distinct functions and regulatory mechanisms in comparison to sleep in maturity. In flies, manipulation of most known adult sleep regulatory genes is not associated with sleep phenotypes during early developmental (larval) stages. Here, we examine the role of the neurodevelopmental disorder-associated gene
(
) in sleep during numerous developmental periods. Mutations in
(
) are associated with sleep and circadian disorders in humans and adult flies. We find in flies that
acts to regulate sleep across the lifespan, beginning during larval stages.
is required in neurons for this function, as is signaling via the Alk pathway. These findings identify
as one of a small number of genes positioned to regulate sleep across developmental periods.</description><subject>Autism</subject><subject>Development</subject><subject>Drosophila</subject><subject>Larvae</subject><subject>Neurofibromatosis</subject><subject>Research Paper</subject><subject>Sleep</subject><issn>2451-9944</issn><issn>2451-9944</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpVkU9PJCEQxcnGzWrUT7CJ6aOXGSn-dMPJGHVXE6OX3TOh6WLsCd20MG3it5dx1OgJeLz6FcUj5DfQJVCoz9bLsc0uLRllvCi0iD_IARMSFloLsfdlv0-Oc17T4tGiFpz9Ivu8kZpTQQ_IxT3OKfq-TXHoxwqqhKs52A3mCm0KL1WHzxjiNOC4saHKAXGqivEqxRynxz7YI_LT25Dx-H09JP__XP-7vFncPfy9vby4WziuGlgoia1Gx2slQTslhGsk4-XApQBPdS20ZqAV8JYCeK8E1YIKZxtehqslPyS3O24X7dpMqR9sejHR9uZNiGllbNr0LqBRFrum8zXoAved1KCYYi3T0oMHumWd71jT3A7YuTJcsuEb9PvN2D-aVXw2QAVTtIFCOH0npPg0Y96Yoc8OQ7AjxjkbpiTXomlEXax8Z3Xlz3JC_9kHqNmGadbmLUyzDdPswixVJ1-f-FnzER1_BZfpmd8</recordid><startdate>20231101</startdate><enddate>20231101</enddate><creator>Durkin, Jaclyn</creator><creator>Poe, Amy R</creator><creator>Belfer, Samuel J</creator><creator>Rodriguez, Anyara</creator><creator>Tang, Si Hao</creator><creator>Walker, James A</creator><creator>Kayser, Matthew S</creator><general>Elsevier</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-2359-4967</orcidid></search><sort><creationdate>20231101</creationdate><title>Neurofibromin 1 regulates early developmental sleep in Drosophila</title><author>Durkin, Jaclyn ; Poe, Amy R ; Belfer, Samuel J ; Rodriguez, Anyara ; Tang, Si Hao ; Walker, James A ; Kayser, Matthew S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3871-85eb9ec368519c844c75238513541f096499219813b011ff8409404ca73010653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Autism</topic><topic>Development</topic><topic>Drosophila</topic><topic>Larvae</topic><topic>Neurofibromatosis</topic><topic>Research Paper</topic><topic>Sleep</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Durkin, Jaclyn</creatorcontrib><creatorcontrib>Poe, Amy R</creatorcontrib><creatorcontrib>Belfer, Samuel J</creatorcontrib><creatorcontrib>Rodriguez, Anyara</creatorcontrib><creatorcontrib>Tang, Si Hao</creatorcontrib><creatorcontrib>Walker, James A</creatorcontrib><creatorcontrib>Kayser, Matthew S</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Neurobiology of sleep and circadian rhythms</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Durkin, Jaclyn</au><au>Poe, Amy R</au><au>Belfer, Samuel J</au><au>Rodriguez, Anyara</au><au>Tang, Si Hao</au><au>Walker, James A</au><au>Kayser, Matthew S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neurofibromin 1 regulates early developmental sleep in Drosophila</atitle><jtitle>Neurobiology of sleep and circadian rhythms</jtitle><addtitle>Neurobiol Sleep Circadian Rhythms</addtitle><date>2023-11-01</date><risdate>2023</risdate><volume>15</volume><spage>100101</spage><pages>100101-</pages><artnum>100101</artnum><issn>2451-9944</issn><eissn>2451-9944</eissn><abstract>Sleep disturbances are common in neurodevelopmental disorders, but knowledge of molecular factors that govern sleep in young animals is lacking. Evidence across species, including
, suggests that juvenile sleep has distinct functions and regulatory mechanisms in comparison to sleep in maturity. In flies, manipulation of most known adult sleep regulatory genes is not associated with sleep phenotypes during early developmental (larval) stages. Here, we examine the role of the neurodevelopmental disorder-associated gene
(
) in sleep during numerous developmental periods. Mutations in
(
) are associated with sleep and circadian disorders in humans and adult flies. We find in flies that
acts to regulate sleep across the lifespan, beginning during larval stages.
is required in neurons for this function, as is signaling via the Alk pathway. These findings identify
as one of a small number of genes positioned to regulate sleep across developmental periods.</abstract><cop>United States</cop><pub>Elsevier</pub><pmid>37593040</pmid><doi>10.1016/j.nbscr.2023.100101</doi><orcidid>https://orcid.org/0000-0003-2359-4967</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Neurobiology of sleep and circadian rhythms, 2023-11, Vol.15, p.100101, Article 100101 |
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| source | Open Access: PubMed Central; ScienceDirect (Online service) |
| subjects | Autism Development Drosophila Larvae Neurofibromatosis Research Paper Sleep |
| title | Neurofibromin 1 regulates early developmental sleep in Drosophila |
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