The PUF Protein Family: Overview on PUF RNA Targets, Biological Functions, and Post Transcriptional Regulation

Post-transcriptional regulation of gene expression plays a crucial role in many processes. In cells, it is mediated by diverse RNA-binding proteins. These proteins can influence mRNA stability, translation, and localization. The PUF protein family (Pumilio and FBF) is composed of RNA-binding protein...

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Bibliographic Details
Published in:International journal of molecular sciences 2018-01, Vol.19 (2), p.410
Main Authors: Wang, Ming, Ogé, Laurent, Perez-Garcia, Maria-Dolores, Hamama, Latifa, Sakr, Soulaiman
Format: Article
Language:English
Subjects:
Agricultural sciences
Arabidopsis thaliana
Binding
Botanics
Caenorhabditis elegans
Development Biology
Drosophila melanogaster
Eukaryotes
Gene expression
Gene regulation
Insects
Life Sciences
Localization
mRNA stability
Nematodes
plant
Post-transcription
post-transcriptional
Proteins
PUF protein
regulation
Review
Ribonucleic acid
RNA
RNA-binding motifs
RNA-binding protein
Saccharomyces cerevisiae
Vegetal Biology
Yeast
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Summary:Post-transcriptional regulation of gene expression plays a crucial role in many processes. In cells, it is mediated by diverse RNA-binding proteins. These proteins can influence mRNA stability, translation, and localization. The PUF protein family (Pumilio and FBF) is composed of RNA-binding proteins highly conserved among most eukaryotic organisms. Previous investigations indicated that they could be involved in many processes by binding corresponding motifs in the 3'UTR or by interacting with other proteins. To date, most of the investigations on PUF proteins have been focused on , , and , while only a few have been conducted on . The present article provides an overview of the PUF protein family. It addresses their RNA-binding motifs, biological functions, and post-transcriptional control mechanisms in , , , and . These items of knowledge open onto new investigations into the relevance of PUF proteins in specific plant developmental processes.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms19020410