Exploring Flow Procedures for Diazonium Formation

The synthesis of diazonium salts is historically an important transformation extensively utilized in dye manufacture. However the highly reactive nature of the diazonium functionality has additionally led to the development of many new reactions including several carbon-carbon bond forming processes...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2016-07, Vol.21 (7), p.918
Main Authors: Hu, Te, Baxendale, Ian R, Baumann, Marcus
Format: Article
Language:English
Subjects:
Chemistry Techniques, Synthetic
Diazonium Compounds - chemical synthesis
Diazonium Compounds - chemistry
diazonium salts
flow chemistry
meso reactor
processing
Solid-Phase Synthesis Techniques
supported reagent
Temperature
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Summary:The synthesis of diazonium salts is historically an important transformation extensively utilized in dye manufacture. However the highly reactive nature of the diazonium functionality has additionally led to the development of many new reactions including several carbon-carbon bond forming processes. It is therefore highly desirable to determine optimum conditions for the formation of diazonium compounds utilizing the latest processing tools such as flow chemistry to take advantage of the increased safety and continuous manufacturing capabilities. Herein we report a series of flow-based procedures to prepare diazonium salts for subsequent in-situ consumption.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules21070918