The Neutrophil-to-Monocyte Ratio and Platelet-to-White Blood Cell Ratio Represent Novel Prognostic Markers in Patients with Pancreatic Cancer

Background. Inflammation plays an important role in the development of tumors. Several serum based-markers and ratios have been investigated for their prognostic value in pancreatic cancer. However, the prognostic value of the neutrophil-to-monocyte ratio (NMR) and platelet-to-white blood cell ratio...

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Published in:Gastroenterology research and practice 2021, Vol.2021, p.6693028-9
Main Authors: Tang, Feng, Dai, Penghui, Wei, Qiongqiong, Gan, Ke, Wang, Zijie, Chen, Huan, Li, Ting, Lv, Muhan, Deng, Mingming, Luo, Gang
Format: Article
Language:English
Subjects:
Blood
Blood platelets
Cancer
Care and treatment
Comparative analysis
Development and progression
Inflammation
Lymphocytes
Medical prognosis
Neutrophils
Nuclear magnetic resonance
Pancreatic cancer
Prognosis
Tumors
Variables
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Summary:Background. Inflammation plays an important role in the development of tumors. Several serum based-markers and ratios have been investigated for their prognostic value in pancreatic cancer. However, the prognostic value of the neutrophil-to-monocyte ratio (NMR) and platelet-to-white blood cell ratio (PWR) for patients with pancreatic cancer has scarcely been investigated. Methods. From October 2013 to November 2018, a retrospective cohort study was performed on 269 pancreatic cancer patients without treatment. Receiver operating characteristic curves were generated, and areas under the curve were compared for the evaluation of the discriminatory ability of inflammation-based prognostic scoring systems. Kaplan-Meier curves and the Cox proportional hazard model were employed to analyze the relationships among NMR, PWR, and overall survival (OS). Results. The optimal cutoff values of NMR and PWR were 48 and 6, respectively. In univariate analysis, the survival time of NMR>48 and PWR≤6 was shorter than that of NMR≤48 and PWR>6 in patients with pancreatic cancer (P
ISSN:1687-6121
1687-630X
DOI:10.1155/2021/6693028