Water-Solubilization of P(V) and Sb(V) Porphyrins and Their Photobiological Application

Porphyrins have been widely utilized as biochemical and biological functional chromophores which can operate under visible-light irradiation. Water-soluble porphyrins have been used as the drug for photodynamic therapy (PDT) and photodynamic inactivation (PDI). Although usual water-solubilization of...

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Bibliographic Details
Published in:International journal of photoenergy 2015-01, Vol.2015 (2015), p.1-12
Main Authors: Yasuda, Masahide, Hirakawa, Kazutaka, Shiragami, Tsutomu, Matsumoto, Jin
Format: Article
Language:English
Subjects:
Antimony
Aqueous solutions
Biochemistry
Biological
Chromophores
Inactivation
Ligands
Molecular weight
Photodynamic therapy
Porphyrins
Rings (mathematics)
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Summary:Porphyrins have been widely utilized as biochemical and biological functional chromophores which can operate under visible-light irradiation. Water-soluble porphyrins have been used as the drug for photodynamic therapy (PDT) and photodynamic inactivation (PDI). Although usual water-solubilization of porphyrins has been achieved by an introduction of an ionic group such as ammonium, pyridinium, sulfonate, phosphonium, or carboxyl to porphyrin ring, we proposed the preparation of water-soluble P and Sb porphyrins by modification of axial ligands. Alkyl (type A), ethylenedioxy (type E), pyridinium (type P), and glucosyl groups (type G) were introduced to axial ligands of Sb and P porphyrins to achieve water-solubilization of Sb porphyrin and P porphyrins. Here, we review their water-soluble P and Sb porphyrins from the standpoints of preparation, bioaffinity, and photosensitized inactivation.
ISSN:1110-662X
1687-529X
DOI:10.1155/2015/148964