RLIP76 Gene Variants are not Associated with Drug Response in Turkish Epilepsy Patients

Approximately 30% of epileptic patients remain untreated, in spite of trials with maximum tolerable doses of more than one drug. The RalA binding protein 1 (RALBP1/RLIP76), a multifunctional, anti-apoptotic, multidrug transporter protein, has been proposed as being responsible for the drug resistanc...

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Bibliographic Details
Published in:Balkan journal of medical genetics 2011-01, Vol.14 (1), p.25-30
Main Authors: Manguoğlu, E, Akdeniz, S, Dündar, N, Duman, Ö, Aktekin, B, Haspolat, Ş, Bilge, U, Özel, D, Lüleci, G
Format: Article
Language:English
Subjects:
Epilepsy
Neuropharmacology
Original
Pharmacogenetics
Polymorphism
RLIP76 gene
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Summary:Approximately 30% of epileptic patients remain untreated, in spite of trials with maximum tolerable doses of more than one drug. The RalA binding protein 1 (RALBP1/RLIP76), a multifunctional, anti-apoptotic, multidrug transporter protein, has been proposed as being responsible for the drug resistance mechanism in epilepsy. We have investigated polymorphic differences in the coding regions and exon-intron boundaries of the RLIP76 gene, between 146 refractory and 155 non refractory epileptic patients in Turkey, using denaturing high performance liquid chromatography (HPLC) and sequencing analysis techniques. We have detected the following sequence variants: c.160-4G>A, c.187C>G, c.1562-38G>A, c.1670+107G>A, c.1670+93G>A, c.1670+96G>A, c.1670+100C>T, c.1670+130C>T, c.1670+131G>C, c.1670+140 G>C, and found no statistically significant correlation between allele frequencies and drug response status. We conclude that sequence variants of this gene are not involved in drug resistance in epilepsy.
ISSN:1311-0160
2199-5761
DOI:10.2478/v10034-011-0014-3