Microbiological Characteristics, Risk Factors, and Short-Term Mortality of Carbapenem-Resistant Enterobacteriaceae Bloodstream Infections in Pediatric Patients in China: A 10-Year Longitudinal Study

• Published in: Infection and drug resistance 2024-01, Vol.17, p.4815-4823
• Main Authors: Liang, Yujian, Zhao, Chenfeng, Lu, Yuhang, Liao, Kang, Kong, Yannan, Hong, Mengzhi, Li, Liubing, Chen, Yili
• Format: Article
• Language: English
• Subjects: carbapenem-resistant enterobacteriaceae，bloodstream infection; Original Research
• ISSN: 1178-6973; 1178-6973
• DOI: 10.2147/IDR.S485001

Carbapenem-resistant (CRE) is rapidly becoming a major threat to hospitalized children worldwide. The purpose of this study was to summarize etiological characteristics and identify risk factors relevant to CRE bloodstream infection (BSI) and short-term mortality among pediatric patients in China. In this study, we included 370 inpatients ≤17 years old with BSI caused by in China from January 2013 to December 2022. By collecting data on demographics, etiological features, and clinical outcomes, we conducted an in-depth analysis. Among the 370 BSI patients with infections caused by , 35 patients (9.46%) were caused by CRE. Among these CRE strains, (49.46%) was the most important pathogen of BSI in pediatric patients, followed by (31.62%) and (5.95%). The most frequent carbapenemase was NDM (23/35, 65.71%), followed by KPC (8/35, 22.86%). The overall 28-day mortality rate of children with an BSI episode was 1.89% (7/370), of which CRE BSI patients (3/35, 8.57%) were significantly higher than CSE patients (4/335, 1.19%, P < 0.001). Congenital malformation (OR: 8.162, 95% CI: 3.859-16.680, P < 0.001) and catheter-related (OR: 6.645, 95% CI: 3.159-13.28, P: