Biology and Role of Extracellular Vesicles (EVs) in the Pathogenesis of Thrombosis

Extracellular vesicles (EVs) are well-established mediators of cell-to-cell communication. EVs can be released by every cell type and they can be classified into three major groups according to their biogenesis, dimension, density, and predominant protein markers: exosomes, microvesicles, and apopto...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2019-06, Vol.20 (11), p.2840
Main Authors: Zarà, Marta, Guidetti, Gianni Francesco, Camera, Marina, Canobbio, Ilaria, Amadio, Patrizia, Torti, Mauro, Tremoli, Elena, Barbieri, Silvia Stella
Format: Article
Language:English
Subjects:
Animals
Apoptosis
arterial thrombosis
Biology
biomarker
Biomarkers - metabolism
Biosynthesis
Blood platelets
Cell signaling
Chromatography
Classification
Drug delivery
Drug delivery systems
Drug Delivery Systems - methods
Exosomes
Exosomes - metabolism
Extracellular vesicles
Extracellular Vesicles - metabolism
Heart attacks
Homeostasis
Humans
Inflammation
Ischemia
Microscopy
microvesicles
Mortality
Physiology
Proteins
Receptor mechanisms
Review
Stem cells
Therapeutic applications
Thromboembolism
Thrombosis
Thrombosis - metabolism
Tissue engineering
venous thrombosis
Vesicles
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Extracellular vesicles (EVs) are well-established mediators of cell-to-cell communication. EVs can be released by every cell type and they can be classified into three major groups according to their biogenesis, dimension, density, and predominant protein markers: exosomes, microvesicles, and apoptotic bodies. During their formation, EVs associate with specific cargo from their parental cell that can include RNAs, free fatty acids, surface receptors, and proteins. The biological function of EVs is to maintain cellular and tissue homeostasis by transferring critical biological cargos to distal or neighboring recipient cells. On the other hand, their role in intercellular communication may also contribute to the pathogenesis of several diseases, including thrombosis. More recently, their physiological and biochemical properties have suggested their use as a therapeutic tool in tissue regeneration as well as a novel option for drug delivery. In this review, we will summarize the impact of EVs released from blood and vascular cells in arterial and venous thrombosis, describing the mechanisms by which EVs affect thrombosis and their potential clinical applications.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms20112840