Evaluation of anterior mediastinal solid tumors by CT perfusion: a preliminary study

We aimed to assess the role of computed tomography (CT) perfusion in differentiation of thymoma from thymic hyperplasia, lymphoma, thymic carcinoma, and lung cancer invading anterior mediastinum. In this study, 25 patients with an anterior mediastinal lesion underwent CT perfusion imaging from Janua...

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Bibliographic Details
Published in:Diagnostic and interventional radiology (Ankara, Turkey) Turkey), 2017-01, Vol.23 (1), p.10-14
Main Authors: Bakan, Selim, Kandemirli, Sedat Giray, Dikici, Atilla Süleyman, Erşen, Ezel, Yıldırım, Onur, Samancı, Cesur, Batur, Şebnem, Çebi Olgun, Deniz, Kantarcı, Fatih, Akman, Canan
Format: Article
Language:English
Subjects:
Adult
Aged
Analysis
Blood flow
Care and treatment
Chest Imaging
CT imaging
Diagnosis
Diagnosis, Differential
Female
Humans
Ionizing radiation
Magnetic resonance imaging
Male
Mediastinal Neoplasms - diagnostic imaging
Middle Aged
Perfusion Imaging - methods
Prospective Studies
Thymoma
Tomography, X-Ray Computed - methods
Young Adult
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Summary:We aimed to assess the role of computed tomography (CT) perfusion in differentiation of thymoma from thymic hyperplasia, lymphoma, thymic carcinoma, and lung cancer invading anterior mediastinum. In this study, 25 patients with an anterior mediastinal lesion underwent CT perfusion imaging from January 2015 to February 2016. Diagnoses included thymoma (n=7), thymic hyperplasia (n=8), lymphoma (n=4), thymic carcinoma (n=3), and invasive lung cancer (n=3). Lymphoma, thymic carcinoma, and lung cancer were grouped as malignant tumors for statistical analysis. Values for blood flow, blood volume, and permeability surface were measured in CT perfusion. Blood flow and blood volume values were higher in thymoma in comparison to thymic hyperplasia; however, the difference was not statistically significant. Blood volume values were significantly higher in thymoma (mean, 11.4 mL/100 mL; range, 5.2-20.2 mL/100 mL) compared with lymphoma (mean, 5.3 mL/100 mL; range, 2.5-7.2 mL/100 mL) (P = 0.023). Blood flow and blood volume values were significantly higher in thymoma compared with non-thymoma malignant tumors (P = 0.025). CT perfusion is helpful in differentiating thymoma from non-thymoma malignancies including lymphoma, thymic carcinoma, and invasive lung cancer involving the anterior mediastinum.
ISSN:1305-3825
1305-3612
DOI:10.5152/dir.2016.16093