The Significance of Anti-Beta-2-Glycoprotein I Antibodies in Antiphospholipid Syndrome

Antiphospholipid syndrome (APS) is a thrombophilic disorder that classically presents with vascular thrombosis and/or obstetric complications. APS is associated with antiphospholipid antibodies: a heterogeneous group of autoantibodies that are directed against membrane phospholipids in complex with...

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Published in:Antibodies (Basel) 2016-06, Vol.5 (2), p.16
Main Author: Brusch, Anna
Format: Article
Language:English
Subjects:
antiphospholipid antibody
antiphospholipid syndrome
beta-2 glycoprotein I
domain specific antibodies
isotypes
Review
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description Antiphospholipid syndrome (APS) is a thrombophilic disorder that classically presents with vascular thrombosis and/or obstetric complications. APS is associated with antiphospholipid antibodies: a heterogeneous group of autoantibodies that are directed against membrane phospholipids in complex with phospholipid-binding proteins. Beta-2-glycoprotein I (B2GPI) binds anionic phospholipids and is considered to be the predominant antigen in APS and antibodies against B2GPI (anti-B2GPI) are recognised in the laboratory criteria for APS diagnosis. This review focuses on the part played by anti-B2GPI in the pathogenesis of APS, their associations with different clinical phenotypes of the disorder and new avenues for refining the diagnostic potential of anti-B2GPI testing.
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subjects antiphospholipid antibody
antiphospholipid syndrome
beta-2 glycoprotein I
domain specific antibodies
isotypes
Review
title The Significance of Anti-Beta-2-Glycoprotein I Antibodies in Antiphospholipid Syndrome
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