Role of Stem Cells in the Ovarian Tissue Cryopreservation and Transplantation for Fertility Preservation

Although the cancer survival rate has increased, cancer treatments, including chemotherapy and radiotherapy, can cause ovarian failure and infertility in women of reproductive age. Preserving fertility throughout cancer treatment is critical for maintaining quality of life. Fertility experts should...

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Bibliographic Details
Published in:International journal of molecular sciences 2021-11, Vol.22 (22), p.12482
Main Authors: Kim, Jeong Min, Kim, Seongmin, Lee, Sanghoon
Format: Article
Language:English
Subjects:
Angiogenesis
Bone marrow
Cancer therapies
Chemotherapy
Cryopreservation
Embryos
Female
Females
Fertility
Fertility Preservation
Fertilization
Gametocytes
Growth factors
Humans
In vitro fertilization
Infertility
Ischemia
Lymphoma
Mammals
Menstruation
New technology
Oocytes - growth & development
Oocytes - transplantation
Ovarian cancer
Ovarian Follicle - growth & development
Ovarian Follicle - transplantation
ovarian tissue
Ovaries
Oxygenation
Patients
Primary Ovarian Insufficiency - genetics
Primary Ovarian Insufficiency - pathology
Primary Ovarian Insufficiency - prevention & control
Quality of life
Radiation therapy
Reproductive status
Review
stem cell
Stem Cell Transplantation
Stem cells
Stem Cells - cytology
Success
Survival
Transplantation
Transplants & implants
Transposition
Womens health
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Summary:Although the cancer survival rate has increased, cancer treatments, including chemotherapy and radiotherapy, can cause ovarian failure and infertility in women of reproductive age. Preserving fertility throughout cancer treatment is critical for maintaining quality of life. Fertility experts should propose individualized fertility preservation methods based on the patient's marital status, pubertal status, partner status, and the urgency of treatment. Widely practiced fertility preservation methods, including ovarian transposition and embryo and oocyte cryopreservation, are inappropriate for prepubertal girls or those needing urgent initiation of cancer treatment. Ovarian tissue cryopreservation and transplantation, an emerging new technology, may be a solution for these cancer patients. The use of stem cells in ovarian tissue cryopreservation and transplantation increases oxygenation, angiogenesis, and follicle survival rates. This review discusses the recent advances in ovarian tissue cryopreservation and transplantation with special focus on the use of stem cells to improve fertilization techniques.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms222212482